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Heritability of telomere length across three generations of Korean families

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dc.contributor.author이덕철-
dc.contributor.author남정모-
dc.date.accessioned2020-09-28T11:09:53Z-
dc.date.available2020-09-28T11:09:53Z-
dc.date.issued2020-05-
dc.identifier.issn0031-3998-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179177-
dc.description.abstractBackground: Leukocyte telomere length (LTL), an indicator of aging, is influenced by both genetic and environmental factors; however, its heritability is unknown. We determined heritability and inheritance patterns of telomere length across three generations of families. Methods: We analyzed 287 individuals from three generations of 41 Korean families, including newborns, parents, and grandparents. LTL (the ratio of telomere repeat copy number to single gene copy number) was measured by quantitative real-time PCR. We estimated heritability using the SOLAR software maximum-likelihood variance component methods and a pedigree dataset. With adjustment for age and length of marriage, Pearson's partial correlation was performed for spousal pairs. Results: Heritability of LTL was high in all participants (h2 = 0.64). There were no significant differences in correlation coefficients of telomere length between paternal and maternal lines. There was a positive LTL correlation in grandfather-grandmother pairs (r = 0.25, p = 0.03) but not in father-mother pairs. After adjusting for age and length of marriage, the relationship between telomere lengths in grandfathers and grandmothers disappeared. There were inverse correlations between spousal rank differences of telomere length and length of marriage. Conclusions: LTL is highly heritable without a sex-specific inheritance pattern and may be influenced by a shared environment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Publishing Group-
dc.relation.isPartOfPEDIATRIC RESEARCH-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleHeritability of telomere length across three generations of Korean families-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Family Medicine (가정의학교실)-
dc.contributor.googleauthorJung-Ha Kim-
dc.contributor.googleauthorChung Mo Nam-
dc.contributor.googleauthorDonghee Lee-
dc.contributor.googleauthorHyoweon Bang-
dc.contributor.googleauthorJae-Hong Ko-
dc.contributor.googleauthorInja Lim-
dc.contributor.googleauthorGwang Jun Kim-
dc.contributor.googleauthorBart W Koes-
dc.contributor.googleauthorDuk-Chul Lee-
dc.identifier.doi10.1038/s41390-019-0699-7-
dc.contributor.localIdA02716-
dc.contributor.localIdA01264-
dc.contributor.localIdA01264-
dc.relation.journalcodeJ02493-
dc.identifier.eissn1530-0447-
dc.identifier.pmid31783399-
dc.contributor.alternativeNameLee, Duk Chul-
dc.contributor.affiliatedAuthor이덕철-
dc.contributor.affiliatedAuthor남정모-
dc.contributor.affiliatedAuthor남정모-
dc.citation.volume87-
dc.citation.number6-
dc.citation.startPage1060-
dc.citation.endPage1065-
dc.identifier.bibliographicCitationPEDIATRIC RESEARCH, Vol.87(6) : 1060-1065, 2020-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers

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