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Clinical associations of renal involvement in ANCA-associated vasculitis

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dc.contributor.author신재일-
dc.contributor.author이금화-
dc.date.accessioned2020-09-28T10:34:16Z-
dc.date.available2020-09-28T10:34:16Z-
dc.date.issued2020-04-
dc.identifier.issn1568-9972-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/179147-
dc.description.abstractObjective: Renal involvement in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis is associated with significant morbidity and higher mortality rates. This study examined clinical manifestations associated with renal involvement in ANCA-associated vasculitis within a large, international cross-sectional cohort. Methods: Univariate and multivariate analyses were performed to identify clinical factors associated with renal disease, which was defined as i) a serum-creatinine >30% above normal and a fall in creatinine-clearance >25%; or ii) haematuria attributable to active vasculitis. Results: The study cohort include 1230 patients from 31 countries; 723 (58.8%) presented with renal involvement: microscopic polyangiitis (82.2%), granulomatosis with polyangiitis (58.6%), and eosinophilic granulomatosis with polyangiitis (26.4%). The following clinical and laboratory factors were more common among patients with renal disease: age (OR 1.01, 95% CI 1.01-1.02), fever (OR 1.97, 95% CI 1.35-2.88), fatigue (OR 1.55, 95% CI 1.14-2.10), weight loss (OR 1.62, 95% CI 1.23-2.12), polyarthritis (OR 1.39, 95% CI 1.02-1.89), petechiae/purpura (OR 1.47, 95% CI 1.06-2.05), pulmonary haemorrhage (OR 5.23, 95% CI 1.39-19.63), gastrointestinal symptoms (OR 2.19, 95% CI 1.34-3.58), seizures (OR 3.42, 95% CI 1.26-9.30), lower serum albumin (OR 2.42, 95% CI 1.64-3.57), higher CRP (OR 2.06, 95% CI 1.04-4.06), low serum C3 at baseline (OR 3.86, 95% CI 1.30-11.53), myeloperoxidase- (OR 7.97, 95% CI 2.74-23.20) and proteinase 3-ANCA (OR 3.40, 95% CI 1.22-9.50). The following clinical factors were less common among patients with renal disease: mononeuritis multiplex (OR 0.63, 95% CI 0.41-0.98), proptosis/exophthalmos (OR 0.19, 95% CI 0.06-0.59), nasal polyps (OR 0.32, 95% CI 0.19-0.55), septal defect/perforation (OR 0.29, 95% CI 0.14-0.60), respiratory distress/pulmonary fibrosis/asthma (OR 0.08, 95% CI 0.04-0.19), and wheeze/obstructive airway disease (OR 0.29, 95% CI 0.16-0.52). Conclusion: In this large international study, several clinical and laboratory factors were identified as associated with renal involvement in ANCA-associated vasculitis.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfAUTOIMMUNITY REVIEWS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.subject.MESHAnti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / complications*-
dc.subject.MESHChurg-Strauss Syndrome-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHGranulomatosis with Polyangiitis-
dc.subject.MESHHumans-
dc.subject.MESHKidney Diseases / complications*-
dc.titleClinical associations of renal involvement in ANCA-associated vasculitis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Pediatrics (소아청소년과학교실)-
dc.contributor.googleauthorAndreas Kronbichler-
dc.contributor.googleauthorJae Il Shin-
dc.contributor.googleauthorKeum Hwa Lee-
dc.contributor.googleauthorDaiki Nakagomi-
dc.contributor.googleauthorLuis F Quintana-
dc.contributor.googleauthorMartin Busch-
dc.contributor.googleauthorAnthea Craven-
dc.contributor.googleauthorRaashid A Luqmani-
dc.contributor.googleauthorPeter A Merkel-
dc.contributor.googleauthorGert Mayer-
dc.contributor.googleauthorDavid R W Jayne-
dc.contributor.googleauthorRichard A Watts-
dc.identifier.doi10.1016/j.autrev.2020.102495-
dc.contributor.localIdA02142-
dc.contributor.localIdA04622-
dc.relation.journalcodeJ03068-
dc.identifier.eissn1873-0183-
dc.identifier.pmid32068190-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1568997220300434-
dc.subject.keywordANCA-
dc.subject.keywordKidney involvement-
dc.subject.keywordRenal vasculitis-
dc.contributor.alternativeNameShin, Jae Il-
dc.contributor.affiliatedAuthor신재일-
dc.contributor.affiliatedAuthor이금화-
dc.citation.volume19-
dc.citation.number4-
dc.citation.startPage102495-
dc.identifier.bibliographicCitationAUTOIMMUNITY REVIEWS, Vol.19(4) : 102495, 2020-04-
dc.identifier.rimsid67511-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아과학교실) > 1. Journal Papers

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