Cited 40 times in
Clinical associations of renal involvement in ANCA-associated vasculitis
DC Field | Value | Language |
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dc.contributor.author | 신재일 | - |
dc.contributor.author | 이금화 | - |
dc.date.accessioned | 2020-09-28T10:34:16Z | - |
dc.date.available | 2020-09-28T10:34:16Z | - |
dc.date.issued | 2020-04 | - |
dc.identifier.issn | 1568-9972 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/179147 | - |
dc.description.abstract | Objective: Renal involvement in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis is associated with significant morbidity and higher mortality rates. This study examined clinical manifestations associated with renal involvement in ANCA-associated vasculitis within a large, international cross-sectional cohort. Methods: Univariate and multivariate analyses were performed to identify clinical factors associated with renal disease, which was defined as i) a serum-creatinine >30% above normal and a fall in creatinine-clearance >25%; or ii) haematuria attributable to active vasculitis. Results: The study cohort include 1230 patients from 31 countries; 723 (58.8%) presented with renal involvement: microscopic polyangiitis (82.2%), granulomatosis with polyangiitis (58.6%), and eosinophilic granulomatosis with polyangiitis (26.4%). The following clinical and laboratory factors were more common among patients with renal disease: age (OR 1.01, 95% CI 1.01-1.02), fever (OR 1.97, 95% CI 1.35-2.88), fatigue (OR 1.55, 95% CI 1.14-2.10), weight loss (OR 1.62, 95% CI 1.23-2.12), polyarthritis (OR 1.39, 95% CI 1.02-1.89), petechiae/purpura (OR 1.47, 95% CI 1.06-2.05), pulmonary haemorrhage (OR 5.23, 95% CI 1.39-19.63), gastrointestinal symptoms (OR 2.19, 95% CI 1.34-3.58), seizures (OR 3.42, 95% CI 1.26-9.30), lower serum albumin (OR 2.42, 95% CI 1.64-3.57), higher CRP (OR 2.06, 95% CI 1.04-4.06), low serum C3 at baseline (OR 3.86, 95% CI 1.30-11.53), myeloperoxidase- (OR 7.97, 95% CI 2.74-23.20) and proteinase 3-ANCA (OR 3.40, 95% CI 1.22-9.50). The following clinical factors were less common among patients with renal disease: mononeuritis multiplex (OR 0.63, 95% CI 0.41-0.98), proptosis/exophthalmos (OR 0.19, 95% CI 0.06-0.59), nasal polyps (OR 0.32, 95% CI 0.19-0.55), septal defect/perforation (OR 0.29, 95% CI 0.14-0.60), respiratory distress/pulmonary fibrosis/asthma (OR 0.08, 95% CI 0.04-0.19), and wheeze/obstructive airway disease (OR 0.29, 95% CI 0.16-0.52). Conclusion: In this large international study, several clinical and laboratory factors were identified as associated with renal involvement in ANCA-associated vasculitis. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | AUTOIMMUNITY REVIEWS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / complications* | - |
dc.subject.MESH | Churg-Strauss Syndrome | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Granulomatosis with Polyangiitis | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kidney Diseases / complications* | - |
dc.title | Clinical associations of renal involvement in ANCA-associated vasculitis | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pediatrics (소아청소년과학교실) | - |
dc.contributor.googleauthor | Andreas Kronbichler | - |
dc.contributor.googleauthor | Jae Il Shin | - |
dc.contributor.googleauthor | Keum Hwa Lee | - |
dc.contributor.googleauthor | Daiki Nakagomi | - |
dc.contributor.googleauthor | Luis F Quintana | - |
dc.contributor.googleauthor | Martin Busch | - |
dc.contributor.googleauthor | Anthea Craven | - |
dc.contributor.googleauthor | Raashid A Luqmani | - |
dc.contributor.googleauthor | Peter A Merkel | - |
dc.contributor.googleauthor | Gert Mayer | - |
dc.contributor.googleauthor | David R W Jayne | - |
dc.contributor.googleauthor | Richard A Watts | - |
dc.identifier.doi | 10.1016/j.autrev.2020.102495 | - |
dc.contributor.localId | A02142 | - |
dc.contributor.localId | A04622 | - |
dc.relation.journalcode | J03068 | - |
dc.identifier.eissn | 1873-0183 | - |
dc.identifier.pmid | 32068190 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1568997220300434 | - |
dc.subject.keyword | ANCA | - |
dc.subject.keyword | Kidney involvement | - |
dc.subject.keyword | Renal vasculitis | - |
dc.contributor.alternativeName | Shin, Jae Il | - |
dc.contributor.affiliatedAuthor | 신재일 | - |
dc.contributor.affiliatedAuthor | 이금화 | - |
dc.citation.volume | 19 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 102495 | - |
dc.identifier.bibliographicCitation | AUTOIMMUNITY REVIEWS, Vol.19(4) : 102495, 2020-04 | - |
dc.identifier.rimsid | 67511 | - |
dc.type.rims | ART | - |
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