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Customized FreeSurfer-based brain atlas for diffeomorphic anatomical registration through exponentiated lie algebra tool

Authors
 Min Seok Baek  ;  Hanna Cho  ;  Young Hoon Ryu  ;  Chul Hyoung Lyoo 
Citation
 ANNALS OF NUCLEAR MEDICINE, Vol.34(4) : 280-288, 2020-04 
Journal Title
 ANNALS OF NUCLEAR MEDICINE 
ISSN
 0914-7187 
Issue Date
2020-04
Keywords
Atlas ; DARTEL ; FreeSurfer ; Magnetic resonance imaging ; Positron emission tomography ; Template
Abstract
Objective: Digital brain template and atlas designed for a specific group provide advantages for the analysis and interpretation of neuroimaging data, but require a significant workload for development. We developed a simple method to create customized brain atlas for diffeomorphic anatomical registration through exponentiated lie algebra (DARTEL) tool using FreeSurfer-generated volume-of-interest (FSVOI) images and validated. Methods: 18F-florbetaben positron emission tomography (PET) and magnetic resonance (MR) imaging data were obtained from 248 participants of Alzheimer's disease spectrum (from cognitively normal to Alzheimer's disease dementia). To create a customized atlas, MR images of 84 amyloid-negative controls were first processed with FreeSurfer to obtain individual FSVOI and with DARTEL tool to create DARTEL template. Individual FSVOI images were spatially normalized, and each voxel was then labelled with a VOI label with maximum probability. Using these template and atlas, all images were normalized, and the regional standardized uptake value ratios (SUVR) were measured. Results: 18F-florbetaben SUVR values measured with customized atlas showed excellent one-to-one correlation with SUVR measured with individual FSVOI in all regions, and thereby showed almost identical between-group comparison results and outperformed the classic methods. Conclusions: Customized FreeSurfer-based brain atlas for DARTEL tool is easy to create and useful for the analysis of PET and MR images with high adaptability and reliability for broad research purposes.
Full Text
https://link.springer.com/article/10.1007/s12149-020-01445-y
DOI
10.1007/s12149-020-01445-y
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Baek, Min Seok(백민석) ORCID logo https://orcid.org/0000-0001-5250-9480
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179144
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