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Effectiveness of Mass Drug Administration on Neglected Tropical Diseases in Schoolchildren in Zanzibar, Tanzania

Authors
 Ju Yeong Kim  ;  Seobo Sim  ;  Eun Joo Chung  ;  Han-Jong Rim  ;  Jong-Yil Chai  ;  Duk-Young Min  ;  Keeseon S Eom  ;  Khalfan A Mohammed  ;  Iddi S Khamis  ;  Tai-Soon Yong 
Citation
 KOREAN JOURNAL OF PARASITOLOGY, Vol.58(2) : 109-119, 2020-04 
Journal Title
 KOREAN JOURNAL OF PARASITOLOGY 
ISSN
 0023-4001 
Issue Date
2020-04
MeSH
Cetrimonium Compounds ; Child ; Cohort Studies ; Drug Combinations ; Female ; Helminthiasis / drug therapy* ; Helminthiasis / epidemiology ; Helminthiasis / parasitology ; Helminthiasis / prevention & control* ; Humans ; Male ; Mass Drug Administration* ; Mass Screening ; Myristates ; Negative Results ; Neglected Diseases* ; Nicotinic Acids ; Schistosomiasis haematobia / drug therapy* ; Schistosomiasis haematobia / epidemiology ; Schistosomiasis haematobia / prevention & control* ; Simethicone ; Stearic Acids ; Tanzania / epidemiology
Keywords
Schistosoma haematobium ; Zanzibar ; mass drug administration ; neglected tropical disease ; soil-transmitted helminth
Abstract
Soil-transmitted helminths and Schistosoma haematobium affect more than 3 billion people globally and mainly occur in sub-Saharan Africa. The present study assessed the overall infection status of a 1716-student cohort of school-children in Zanzibar and applied mass drug administration (MDA) to the cohort from 2007 to 2009. Schools in Pemba, Zanzibar, had a much higher prevalence of soil-transmitted helminth infections than those in Unguja, and the Chaani, Ghana, and Machui schools of Unguja exhibited high S. haematobium infection rates. The MDA program only partially controlled parasite infections, owing to high rates of re-infection. The infection rate of S. haematobium across all 10 schools, for example, was only reduced by 1.8%, and even this change not significant, even though the S. haematobiuminfection rates of the Chaani and Mzambarauni schools were significantly reduced from 64.4 and 23.4%, respectively, at the first screening, to 7.3 and 2.3% at the last screening. The overall infection rate of Ascaris lumbricoides was reduced from 36.0% at the first screening to 22.6% at the last screening. However, the infection rates for both Trichuris trichiuraand hookworm were generally unaffected by MDA. In the future, parasite control programs should involve strategically designed MDA schedules and holistic intervention (e.g., sanitation improvement, hygiene behavior changes, and control of intermediated hosts).
Files in This Item:
T202002692.pdf Download
DOI
10.3347/kjp.2020.58.2.109
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Environmental Medical Biology (환경의생물학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ju Young(김주영) ORCID logo https://orcid.org/0000-0003-2456-6298
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179118
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