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Understanding the immunopathogenesis of autoimmune diseases by animal studies using gene modulation: A comprehensive review

Authors
 Keum Hwa Lee  ;  Byung Soo Ahn  ;  Dohyeon Cha  ;  Won Woo Jang  ;  Eugene Choi  ;  Soohyun Park  ;  Jun Hyeong Park  ;  Junseok Oh  ;  Da Eun Jung  ;  Heeryun Park  ;  Ju Ha Park  ;  Youngsong Suh  ;  Dongwan Jin  ;  Siyeon Lee  ;  Yong-Hwan Jang  ;  Tehwook Yoon  ;  Min-Kyu Park  ;  Yoonje Seong  ;  Jihoon Pyo  ;  Sunmo Yang  ;  Youngin Kwon  ;  Hyunjean Jung  ;  Chae Kwang Lim  ;  Jun Beom Hong  ;  Yeoeun Park  ;  Eunjin Choi  ;  Jae Il Shin  ;  Andreas Kronbichler 
Citation
 AUTOIMMUNITY REVIEWS, Vol.19(3) : 102469, 2020-03 
Journal Title
 AUTOIMMUNITY REVIEWS 
ISSN
 1568-9972 
Issue Date
2020-03
MeSH
Animals ; Arthritis, Rheumatoid ; Autoimmune Diseases / genetics* ; Autoimmune Diseases / immunology* ; Cytokines / immunology ; Disease Models, Animal* ; Humans ; Inflammatory Bowel Diseases ; Lupus Erythematosus, Systemic ; Multiple Sclerosis
Keywords
Animal studies ; Autoimmune diseases ; Gene modulation ; Immunopathogenesis
Abstract
Autoimmune diseases are clinical syndromes that result from pathogenic inflammatory responses driven by inadequate immune activation by T- and B-cells. Although the exact mechanisms of autoimmune diseases are still elusive, genetic factors also play an important role in the pathogenesis. Recently, with the advancement of understanding of the immunological and molecular basis of autoimmune diseases, gene modulation has become a potential approach for the tailored treatment of autoimmune disorders. Gene modulation can be applied to regulate the levels of interleukins (IL), tumor necrosis factor (TNF), cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4), interferon-γ and other inflammatory cytokines by inhibiting these cytokine expressions using short interfering ribonucleic acid (siRNA) or by inhibiting cytokine signaling using small molecules. In addition, gene modulation delivering anti-inflammatory cytokines or cytokine antagonists showed effectiveness in regulating autoimmunity. In this review, we summarize the potential target genes for gene or immunomodulation in autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), inflammatory bowel diseases (IBD) and multiple sclerosis (MS). This article will give a new perspective on understanding immunopathogenesis of autoimmune diseases not only in animals but also in human. Emerging approaches to investigate cytokine regulation through gene modulation may be a potential approach for the tailored immunomodulation of some autoimmune diseases near in the future.
Full Text
https://www.sciencedirect.com/science/article/pii/S1568997220300124
DOI
10.1016/j.autrev.2020.102469
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Shin, Jae Il(신재일) ORCID logo https://orcid.org/0000-0003-2326-1820
Lee, Keum Hwa(이금화) ORCID logo https://orcid.org/0000-0002-1511-9587
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179074
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