0 4

Cited 0 times in

Lung cancer progression using fast switching multiple ion beam radiation and countermeasure prevention

Authors
 Krishna Luitel  ;  Sang Bum Kim  ;  Summer Barron  ;  James A Richardson  ;  Jerry W Shay 
Citation
 LIFE SCIENCES IN SPACE RESEARCH, Vol.24 : 108-115, 2020-02 
Journal Title
 LIFE SCIENCES IN SPACE RESEARCH 
ISSN
 2214-5524 
Issue Date
2020-02
Keywords
CDDO-EA ; GCR simulation ; Ionizing radiation ; Multiple Ions
Abstract
Most of the research in understanding space radiation-induced cancer progression and risk assessment has been performed using mono-energetic single-ion beams. However, the space radiation environment consists of a wide variety of ion species with a various range of energies. Using the fast beam switching technology developed at the NASA Space Radiation Laboratory (NSRL) at Brookhaven National Laboratory (BNL), ion species can be switched rapidly allowing investigators to use multiple ions with different energies to simulate more closely the radiation environment found in space. Here, we exposed a lung cancer susceptible mouse model (K-rasLA-1) to three sequential ion beams: Proton (H) (120 MeV/n) 20 cGy, Helium (He) (250 MeV/n) 5.0 cGy, and Silicon (Si) (300 MeV/n) 5.0 cGy with a dose rate of 0.5 cGy/min. Using three ion beams we performed whole body irradiation with a total dose of 30 cGy in two different orders: 3B-1 (H→He→Si) and 3B-2 (Si→He→H) and used 30 cGy H single-ion beam as a reference. In this study we show that whole-body irradiation with H→He→Si increases the incidence of premalignant lesions and systemic oxidative stress in mice 100 days post-irradiation more than (Si→He→H) and H only irradiation. Additionally, we observed an increase in adenomas with atypia and adenocarcinomas in H→He→Si irradiated mice but not in (Si→He→H) or H (30 cGy) only irradiated mice. When we used the H→He→Si irradiation sequence but skipped a day before exposing the mice to Si, we did not observe the increased incidence of cancer initiation and progression. We also found that a non-toxic anti-inflammatory, anti-oxidative radioprotector (CDDO-EA) reduced H→He→Si induced oxidative stress and cancer initiation almost back to baseline. Thus, exposure to H→He→Si elicits significant changes in lung cancer initiation that can be mitigated using CDDO-EA.
Full Text
https://www.sciencedirect.com/science/article/pii/S2214552419300501
DOI
10.1016/j.lssr.2019.07.011
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
Yonsei Authors
Kim, Sang Bum(김상범) ORCID logo https://orcid.org/0000-0001-5965-3354
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179021
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links