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Updates in the diagnosis of combined hepatocellular-cholangiocarcinoma

Authors
 Amedeo Sciarra  ;  Young Nyun Park  ;  Christine Sempoux 
Citation
 HUMAN PATHOLOGY, Vol.96 : 48-55, 2020-02 
Journal Title
 HUMAN PATHOLOGY 
ISSN
 0046-8177 
Issue Date
2020-02
MeSH
Biomarkers, Tumor / analysis ; Biomarkers, Tumor / genetics ; Biopsy ; Carcinoma, Hepatocellular / chemistry ; Carcinoma, Hepatocellular / genetics ; Carcinoma, Hepatocellular / pathology* ; Carcinoma, Hepatocellular / therapy ; Cholangiocarcinoma / chemistry ; Cholangiocarcinoma / genetics ; Cholangiocarcinoma / pathology* ; Cholangiocarcinoma / therapy ; Humans ; Immunohistochemistry ; Liver Neoplasms / chemistry ; Liver Neoplasms / genetics ; Liver Neoplasms / pathology* ; Liver Neoplasms / therapy ; Molecular Diagnostic Techniques ; Neoplasms, Complex and Mixed / chemistry ; Neoplasms, Complex and Mixed / genetics ; Neoplasms, Complex and Mixed / pathology* ; Neoplasms, Complex and Mixed / therapy ; Predictive Value of Tests ; Prognosis
Keywords
Cholangiocarcinoma ; Cholangiolocarcinoma ; Combined hepatocellular-cholangiocarcinoma ; Hepatocellular carcinoma ; Primary liver carcinoma.
Abstract
Combined hepatocellular-cholangiocarcinoma (cHCC-CCA) is a rare primary liver carcinoma showing variable degrees of differentiation toward hepatocellular and cholangiocellular carcinoma. Its great heterogeneity in term of morphology, immunophenotype, molecular, radiological and clinical features represents a challenge still to overcome. The multidisciplinary 2018 International Consensus on the nomenclature of cHCC-CCA allowed to define key issues of this entity. Here we review the historical controversies of cHCC-CCA, resume the key elements of the 2018 consensus, now incorporated in the 2019 WHO classification, and propose a short survival guide to help surgical pathologists facing cHCC-CCA in their routine workup.
Full Text
https://www.sciencedirect.com/science/article/pii/S0046817719302060
DOI
10.1016/j.humpath.2019.11.001
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Park, Young Nyun(박영년) ORCID logo https://orcid.org/0000-0003-0357-7967
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/179019
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