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Distinct tau PET patterns in atrophy-defined subtypes of Alzheimer's disease

Authors
 Rik Ossenkoppele  ;  Chul Hyoung Lyoo  ;  Carole H Sudre  ;  Danielle van Westen  ;  Hanna Cho  ;  Young Hoon Ryu  ;  Jae Yong Choi  ;  Ruben Smith  ;  Olof Strandberg  ;  Sebastian Palmqvist  ;  Eric Westman  ;  Richard Tsai  ;  Joel Kramer  ;  Adam L Boxer  ;  Maria L Gorno-Tempini  ;  Renaud La Joie  ;  Bruce L Miller  ;  Gil D Rabinovici  ;  Oskar Hansson 
Citation
 ALZHEIMERS & DEMENTIA, Vol.16(2) : 335-344, 2020-02 
Journal Title
 ALZHEIMERS & DEMENTIA 
ISSN
 1552-5260 
Issue Date
2020-02
Keywords
Alzheimer's disease ; Atrophy ; Cognition ; Dementia ; Subtypes ; Tau ; Thickness
Abstract
Introduction: Differential patterns of brain atrophy on structural magnetic resonance imaging (MRI) revealed four reproducible subtypes of Alzheimer's disease (AD): (1) "typical", (2) "limbic-predominant", (3) "hippocampal-sparing", and (4) "mild atrophy". We examined the neurobiological characteristics and clinical progression of these atrophy-defined subtypes. Methods: The four subtypes were replicated using a clustering method on MRI data in 260 amyloid-β-positive patients with mild cognitive impairment or AD dementia, and we subsequently tested whether the subtypes differed on [18 F]flortaucipir (tau) positron emission tomography, white matter hyperintensity burden, and rate of global cognitive decline. Results: Voxel-wise and region-of-interest analyses revealed the greatest neocortical tau load in hippocampal-sparing (frontoparietal-predominant) and typical (temporal-predominant) patients, while limbic-predominant patients showed particularly high entorhinal tau. Typical patients with AD had the most pronounced white matter hyperintensity load, and hippocampal-sparing patients showed the most rapid global cognitive decline. Discussion: Our data suggest that structural MRI can be used to identify biologically and clinically meaningful subtypes of AD.
Files in This Item:
T202002702.pdf Download
DOI
10.1016/j.jalz.2019.08.201
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Ryu, Young Hoon(유영훈) ORCID logo https://orcid.org/0000-0002-9000-5563
Cho, Hanna(조한나) ORCID logo https://orcid.org/0000-0001-5936-1546
Choi, Jae Yong(최재용)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178996
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