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Detection of epileptogenic focus using advanced dynamic statistical parametric mapping with magnetoencephalography in a patient with MRI-negative focal cortical dysplasia type IIB

Authors
 Won Seok Chang  ;  Midori Nakajima  ;  Ayako Ochi  ;  Elysa Widjaja  ;  James T Rutka  ;  Ivanna Yau  ;  Shiro Baba  ;  Hiroshi Otsubo 
Citation
 JOURNAL OF NEUROSURGERY-PEDIATRICS, Vol.25(1) : 78-82, 2020-01 
Journal Title
JOURNAL OF NEUROSURGERY-PEDIATRICS
ISSN
 1933-0707 
Issue Date
2020-01
Keywords
AdSPM = advanced dynamic statistical parametric mapping ; BOSD = bottom-of-sulcus dysplasia ; EEG = electroencephalography ; FCD = focal cortical dysplasia ; MEG = magnetoencephalography ; dSPM = dynamic statistical parametric mapping ; epilepsy ; focal cortical dysplasia ; magnetic resonance image ; mapping
Abstract
Advanced dynamic statistical parametric mapping (AdSPM) with magnetoencephalography (MEG) was used to identify MRI-negative epileptogenic lesions in this report. A 15-year-old girl had MRI-negative and pharmacology-resistant focal-onset epilepsy. She experienced two types of seizures. Type I consisted of her arousal from sleep, staring, and a forced head-turning movement to the left, followed by secondary generalization. Type II began with an aura of dizziness followed by staring and postictal headache with fatigue. Scalp video-electroencephalography (EEG) captured two type I seizures originating from the right frontocentral region. MEG showed scattered dipoles over the right frontal region. AdSPM identified the spike source at the bottom of the right inferior frontal sulcus. Intracranial video-EEG captured one type I seizure, which originated from the depth electrode at the bottom of the sulcus and correlated with the AdSPM spike source. Accordingly, the patient underwent resection of the middle and inferior frontal gyri, including the AdSPM-identified spike source. Histopathological examination revealed that the patient had focal cortical dysplasia type IIB. To date, the patient has been seizure free for 2 years while receiving topiramate treatment. This is the first preliminary report to identify MRI-negative epilepsy using AdSPM. Further investigation of AdSPM would be valuable for cases of MRI-negative focal epilepsy.
Full Text
https://thejns.org/pediatrics/view/journals/j-neurosurg-pediatr/25/1/article-p78.xml
DOI
10.3171/2019.7.PEDS1948
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
Chang, Won Seok(장원석) ORCID logo https://orcid.org/0000-0003-3145-4016
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178995
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