0 453

Cited 2 times in

Allergen-like Molecules from Parasites

Authors
 Ju Yeong Kim  ;  Myung-Hee Yi  ;  Tai-Soon Yong 
Citation
 CURRENT PROTEIN & PEPTIDE SCIENCE, Vol.21(2) : 186-202, 2020-01 
Journal Title
CURRENT PROTEIN & PEPTIDE SCIENCE
ISSN
 1389-2037 
Issue Date
2020-01
Keywords
Allergen ; Anisakis ; Echinococcus granulosus ; IgE-binding protein ; helminths ; parasite
Abstract
Parasite infections modulate immunologic responses, and the loss of parasite infections in the last two to three decades might explain the increased prevalence of allergic diseases in developed countries. However, parasites can enhance allergic responses. Parasites contain or release allergen-like molecules that induce the specific immunoglobulin, IgE, and trigger type-2 immune responses. Some parasites and their proteins, such as Anisakis and Echinococcus granulosus allergens, act as typical allergens. A number of IgE-binding proteins of various helminthic parasites are cross-reactive to other environmental allergens, which cause allergic symptoms or hamper accurate diagnosis of allergic diseases. The cross-reactivity is based on the fact that parasite proteins are structurally homologous to common environmental allergens. In addition, IgE-binding proteins of parasites might be useful for developing vaccines to prevent host re-infection. This review discusses the functions of the IgE-biding proteins of parasites.
Full Text
https://www.eurekaselect.com/173312/article
DOI
10.2174/1389203720666190708154300
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Tropica Medicine (열대의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Ju Yeong(김주영) ORCID logo https://orcid.org/0000-0003-2456-6298
Yong, Tai Soon(용태순) ORCID logo https://orcid.org/0000-0002-3445-0769
Yi, Myung Hee(이명희) ORCID logo https://orcid.org/0000-0001-9537-5726
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178994
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links