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Diagnosis of an indistinct Leydig cell tumor by positron emission tomography-computed tomography

Authors
 Jinkyoung Kong  ;  Yoo Mee Park  ;  Young Sik Choi  ;  SiHyun Cho  ;  Byung Seok Lee  ;  Joo Hyun Park 
Citation
 Obstetrics & Gynecology Science, Vol.62(3) : 194-198, 2019-03 
Journal Title
 Obstetrics & Gynecology Science 
ISSN
 2287-8572 
Issue Date
2019-03
Keywords
Diagnosis ; PET-CT ; Sertoli-Leydig cell tumor
Abstract
A 51-year-old perimenopausal female patient presented with hirsutism and voice thickening which was started approximately one and a half years ago. Her initial hormone assay revealed elevated plasma testosterone, 5a-dihydrotestosterone, and dehydroepiandrosterone (DHEA) levels and therefore androgen-secreting tumor was first suspected. However, the lesion was inconspicuous on transvaginal sonography, abdominal-pelvic computed tomography (CT) scan, and pelvic magnetic resonance (MRI) imaging. Consequently, 18F-fluorodeoxyglucose (FDG) positron emission tomography-CT was performed, which localized the lesion as a focal FDG uptake within the right adnexa. Total laparoscopic hysterectomy with bilateral salpingo-oophorectomy was performed, and although visible gross mass lesions were not observed intraoperatively, pure Leydig cell tumor was pathologically confirmed within the right ovary. Plasma testosterone, 5a-dihydrotestosterone, and DHEA levels were normalized postoperatively. Clinical signs of virilization were also significantly resolved after 3-months of follow-up.
Files in This Item:
T9992019038.pdf Download
DOI
10.5468/ogs.2019.62.3.194
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Park, Joo Hyun(박주현)
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
Cho, Si Hyun(조시현) ORCID logo https://orcid.org/0000-0003-2718-6645
Choi, Young Sik(최영식) ORCID logo https://orcid.org/0000-0002-1157-4822
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178944
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