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Anti-allodynic effect of bee venom on neuropathic pain in the rat

Authors
 Lee, Bae-Hwan  ;  Chae, Youn-Byoung  ;  Hwang, Hye-Jeong  ;  Choi, Young-Kook  ;  Hahm, Dae-Hyun  ;  Han, Seung-Moo  ;  Kang, Sung-Keel  ;  Lee, Hye-Jung  ;  Pyun, Kwang-Ho  ;  Shim, In-Sop 
Citation
 Oriental Pharmacy and Experimental Medicine, Vol.6(4) : 324-329, 2006-01 
Journal Title
 Oriental Pharmacy and Experimental Medicine 
Issue Date
2006-01
Keywords
Neuropathic pain ; Bee venom ; Zusanli ; Acupuncture ; Morphine
Abstract
Neuropathic pain syndromes resulted from peripheral nerve injury appear to be resistant to conventional analgesics like opioids. However, it has been demonstrated that acupuncture including aqua-acupuncture may be effective in managing neuropathic pain. The present study was conducted to determine if bee venom injection into acupoint ihibits neuropathic pain, which is difficult to be treated by usual analgesics. Under pentobarbital anesthesia, male Sprague-Dawley rats were subjected to neuropathic surgery. Two weeks after nerve injury, mechanical and cold allodynia were tested in order to evaluate the antiallodynic effects of bee venom injection into an acupoint. Intraperitoneal injection of morphine inhibited mechanical allodynia dose-dependently. Bee venom injected into Zusanli acupoint significantly inhibited mechanical and cold allodynia. These results suggest that bee venom-acupuncture as well as morphine is very effective to inhibit mechanical allodynia.
Files in This Item:
T999200601.pdf Download
DOI
10.3742/OPEM.2006.6.4.324
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178912
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