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Thermosensitive Chitosans as Novel Injectable Biomaterials

Authors
 Ho Jin Chung  ;  Jin Woo Bae  ;  Hyung Dal Park  ;  Jin Woo Lee  ;  Ki Dong Park 
Citation
 MACROMOLECULAR SYMPOSIA, Vol.224(1) : 275-286, 2005-04 
Journal Title
 MACROMOLECULAR SYMPOSIA 
Issue Date
2005-04
Abstract
Two kinds of water soluble thermosensitive chitosan copolymers were prepared by graft polymerization of N‐isopropylacrylamide (NIPAAm) onto chitosan using cerium ammonium nitrate (CAN) as an initiator (chitosan‐g‐NIPAAm) and by coupling monocarboxy Pluronic® with chitosan using 1‐ethyl‐3‐(3‐dimethylaminopropyl)‐carbodiimide (EDC) and N‐hydroxysuccin‐imide (NHS) as coupling agents (chitosan‐Pluronic®). The physicochemical properties of the resulting copolymers were characterized and they formed thermally reversible hydrogel, which exhibits a lower critical solution temperature (LCST) at 34°C in aqueous solutions. The human mesenchymal stem cells (hMSCs) were cultured in the chiotsan‐g‐NIPAAm in vitro. Chondrogenic differentiation was induced in the chitosan‐g‐NIPAAm gel. Therefore, chondrogenic differentiated cells from MSCs with a thermo‐sensitive chitosan‐g‐NIPAAm could be used as an injectable cell‐polymer complex. In summary, chitosan‐g‐NIPAAm and chitosan‐Pluronic® attest to their usefulness as injectable materials because of their thermally reversible property and relatively good biocompatibility.
Full Text
https://onlinelibrary.wiley.com/doi/abs/10.1002/masy.200550624
DOI
10.1002/masy.200550624
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178892
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