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Tetramethoxy hydroxyflavone p7F downregulates inflammatory mediators via the inhibition of nuclear factor kappaB

Authors
 Hee-Gu Lee  ;  Hyoson Kim  ;  Won-Keun Oh  ;  Kyung-Ae Yu  ;  Yong-Kyung Choe  ;  Jong-Seog Ahn  ;  Dong-Soo Kim  ;  Soo-Hyun Kim  ;  Charles A Dinarello  ;  Kilhyoun Kim  ;  Do-Young Yoon 
Citation
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, Vol.1030(1) : 555-568, 2004-12 
Journal Title
 ANNALS OF THE NEW YORK ACADEMY OF SCIENCES 
ISSN
 0077-8923 
Issue Date
2004-12
MeSH
Animals ; Anti-Inflammatory Agents / pharmacology* ; Base Sequence ; Blotting, Western ; Cell Line ; DNA Probes ; Dinoprostone / biosynthesis ; Down-Regulation / drug effects* ; Electrophoretic Mobility Shift Assay ; Flavonoids / pharmacology* ; Inflammation Mediators / metabolism* ; Mice ; NF-kappa B / antagonists & inhibitors*
Abstract
Artemisia has been traditionally used in Korean herbal medicine to clear damp heat and to treat uteritis and jaundice. Flavonoids isolated from Artemisia are also known to possess anti-inflammatory activities. In this study, 5,6,3',5'-tetramethoxy 7,4'-hydroxyflavone (p7F) was isolated from Artemisia absinthium. We examined in vitro and in vivo regulatory functions of p7F on the production of nitric oxide (NO), prostaglandin E(2) (PGE(2)), and tumor necrosis factor-alpha (TNF-alpha) as well as the expression of inducible NO synthase (iNOS), cyclooxygenase-2 (COX-2), and collagen-induced arthritis. p7F inhibited the expression or production of proinflammatory mediators such as COX-2/PGE(2) and iNOS/NO in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. p7F also suppressed the serum level of TNF-alpha in mice treated with collagen and inhibited nuclear factor-kappaB (NF-kappaB) activation as well as NF-kappaB promoter activity in RAW 264.7 cells stimulated with LPS. This compound directly inhibited the intracellular accumulation of reactive oxygen species in hydrogen peroxide-stimulated RAW 264.7 cells. p7F has antioxidant activity and inhibits NF-kappaB activation. Taken together, these results suggest that p7F can be clinically applied to the treatment of inflammatory diseases.
Full Text
https://nyaspubs.onlinelibrary.wiley.com/doi/full/10.1196/annals.1329.065
DOI
10.1196/annals.1329.065
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178881
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