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기관내 삽관시 Fentanyl에 의한 심혈관계 안정성은 진정효과에 의한 것인가?

Other Titles
 Does the Fentanyl Contribute Cardiovascular Stability during Endotracheal Intubation by Sedation Effect? 
Authors
 이윤우  ;  조정구  ;  신양식  ;  오경미  ;  심규대 
Citation
 Intravenous Anesthesia (정맥마취), Vol.5(1) : 112-118, 2001-01 
Journal Title
 Intravenous Anesthesia (정맥마취) 
ISSN
 1226-4857 
Issue Date
2001-01
Keywords
Anesthetics ; enflurane ; fentanyl ; Anesthetic techniques ; endotracheal intubation ; Monitoring ; bispectral index ; blood pressure ; heart rate
Abstract
BACKGROUND: Bispectral (BIS) index has been used as an indicator of hypnotic state. Fentanyl is well known for its cardiovascular stability during endotracheal intubation. The purpose of this study is to evaluate fentanyl\'s sedation effect and its contribution to cardiovascular stability during endotracheal intubation under the BIS monitoring. METHODS: Twenty ASA class 1 or 2, patients were randomly allocated to Group I or II with or without fentanyl 1.5 microgram/kg IV during induction, respectively. The BIS, blood pressures and heart rates were measured at before and 2 minutes after fentanyl IV injection, preintubation, 1, 2, 3 and 5 minutes after tracheal intubation. The enflurane concentrations were continuously maintained at 2 Vol%. RESULTS: The BIS at each stage of process were decreased more in Group I than Group II. The systolic and diastolic blood pressures were increased in Group I less than Group II at 1, 2 and 3 minutes after intubation. The heart rates were increased in Group I less than Group II at 1 minutes after intubation. CONCLUSIONS: A small dose of fentanyl reduced BIS and blunted the intubation induced-sympathetic stimulation, and so its sedation effect partly contributed to maintain cardiovascular stability during endotracheal intubation. For the analgesic effect and central vagolytic effect of fentanyl during intubation, we need further studies.
Files in This Item:
T999200102.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Anesthesiology and Pain Medicine (마취통증의학교실) > 1. Journal Papers
Yonsei Authors
Shin, Yang Sik(신양식)
Lee, Youn Woo(이윤우)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178861
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