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Disturbed surround inhibition in focal hand dystonia

Citation
 ANNALS OF NEUROLOGY, Vol.56(4) : 595-599, 2004-10 
Journal Title
 ANNALS OF NEUROLOGY 
ISSN
 0364-5134 
Issue Date
2004-10
MeSH
Aged ; Dystonic Disorders / physiopathology* ; Electric Stimulation / methods ; Electromyography / methods ; Evoked Potentials, Motor / physiology* ; Evoked Potentials, Motor / radiation effects ; Female ; Fingers / physiopathology ; Fingers / radiation effects ; Humans ; Magnetics ; Male ; Middle Aged ; Muscle, Skeletal / physiopathology ; Muscle, Skeletal / radiation effects ; Neural Inhibition / physiology* ; Neural Inhibition / radiation effects ; Time Factors ; Ulnar Nerve / physiopathology ; Ulnar Nerve / radiation effects
Abstract
Disturbances in surround inhibition could account for various movement disorders. Here we test the functional operation of surround inhibition in focal hand dystonia. Transcranial magnetic stimulation was set to be triggered by self-initiated voluntary flexion of the index finger. During this movement, motor-evoked potential amplitudes from the little finger muscle were significantly suppressed in healthy subjects but enhanced in dystonia patients. This result supports the idea that disturbed surround inhibition is a principal pathophysiological mechanism of dystonia.
DOI
10.1002/ana.20270
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Sohn, Young Ho(손영호) ORCID logo https://orcid.org/0000-0001-6533-2610
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178801
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