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IFN-γ Regulates Expression of BRG1 Associated Factor 155/170 and Sensitivity to Steroid in Astrocytes
DC Field | Value | Language |
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dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2020-09-04T02:05:03Z | - |
dc.date.available | 2020-09-04T02:05:03Z | - |
dc.date.issued | 2004-12 | - |
dc.identifier.issn | 1598-2629 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178791 | - |
dc.description.abstract | Background: The expression of BRG1 associated factors (BAF) 155 and BAF 170 in response to IFN-γ or TNF-α was studied in astrocytoma cell lines and primary astrocytes. BAFs are complexed with BRG1 and are also associated with activated glucocorticoid for glucocorticoid trans-activation. Methods: IFN-γ was pretreated for 18 hrs and cells were incubated with IL-1 or TNF-α for 72 hrs or 96 hrs with different concentrations of steroid. Cell death was measured by LDH assay. BAF expression was assayed by RT-PCR. Results: IFN-γ increased cell death by dexamethasone in LN215 cells but not in LN319 cells. The IFN-γ increased the expression of BAF 155 and BAF 170 in adult astrocytes and LN215 cells, but IFN-γ decreased the expression of BAF 155/170 in LN319 cells. The effect of IFN-γ on the expression of BAF was not as clear in fetal astrocytes as it was in adult astrocytes. Conclusion: Our results suggest cytokines produced during immune reaction or immunotherapy may modulate steroid susceptibility of astrocytes and astrocytoma cells by influencing the expression of BAFs. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Korea Society for Immunology : Korean Society of Biological Response Modifiers | - |
dc.relation.isPartOf | IMMUNE NETWORK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | IFN-γ Regulates Expression of BRG1 Associated Factor 155/170 and Sensitivity to Steroid in Astrocytes | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Jung-Hee Lim1, Jeonggi Lee1, Joo Young Park2 and In-Hong Choi1 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J01033 | - |
dc.identifier.eissn | 2092-6685 | - |
dc.subject.keyword | Astrocyte | - |
dc.subject.keyword | steroid | - |
dc.subject.keyword | BAF155/170 | - |
dc.subject.keyword | IFN-γ | - |
dc.contributor.alternativeName | Choi, In Hong | - |
dc.contributor.affiliatedAuthor | 최인홍 | - |
dc.citation.volume | 4 | - |
dc.citation.number | 4 | - |
dc.citation.startPage | 224 | - |
dc.citation.endPage | 228 | - |
dc.identifier.bibliographicCitation | IMMUNE NETWORK, Vol.4(4) : 224-228, 2004-12 | - |
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