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염증성 장질환에서 Azathioprine과 6-Mercaptopurine 맞춤 처방

Other Titles
 Rational Dosing of Azathioprine and 6-Mercaptopurine in Inflammatory Bowel Diseases 
Authors
 김원호  ;  조재희  ;  김태일 
Citation
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.41(6) : 423-437, 2003-06 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
2003-06
Keywords
Azathioprine ; 6-Mercaptopurine ; Colitis ; ulcerative ; Crohn disease ; Immunosuppressive agents
Abstract
Immunosuppressors, 6-mercaptopurine (6-MP) and its prodrug azathioprine, are used frequently for the treatment of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn`s disease and primarily for the maintenance of remission. The 6-MP is either inactivated to 6-methylmercaptopurine by thiopurine methyltransferase (TPMT) or to 6-thiouric acid by xanthine oxidase. On the other hand, it can be activated via a multistep enzymatic pathway to the putative active metabolites, 6-thioguanine nucleotides (6-TGN). Clinical responsiveness and side effects are associated with TPMT genotype and phenotype because the enzymatic activity of TPMT is genetically determined. Until now, significant proportion of patients with proper indication are not using immunosuppressors because of safety concern and delayed onset of action. Recently, gastroenterologists who accept immunomodulators as the treatment method for IBD are increasing on the basis of favorable results regarding efficacy and safety. The recent application of pharmacogenetics, the study on variability of drug response due to genetic factors, has provided a chance for tailoring doses in the individual patients.
Files in This Item:
T200307636.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Ho(김원호) ORCID logo https://orcid.org/0000-0002-5682-9972
Kim, Tae Il(김태일) ORCID logo https://orcid.org/0000-0003-4807-890X
Cho, Jae Hee(조재희)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178760
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