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만성 췌장염 환자의 대변 내 췌장 Elastase-1

Other Titles
 Fecal Pancreatic Elastase-1 in Patients with Chronic Pancreatitis 
 이진헌  ;  정재복  ;  박윤희  ;  서정훈  ;  박승우  ;  이세준  ;  정준표  ;  송시영  ;  강진경 
 Korean Journal of Pancreas and Biliary Tract (대한췌담도학회지), Vol.5(1) : 1-6, 2000-01 
Journal Title
 Korean Journal of Pancreas and Biliary Tract (대한췌담도학회지) 
Issue Date
Chronic pancreatitis ; Pancreatic elastase-1 ; ERCP ; Cambridge grading
Background/Aims: Recently, fecal pancreatic elastase-1 assay was characterized as a another option for more accurate indirect pancreatic function tests in chronic pancreatitis. The aim of this study was to evaluate the clinical role of fecal pancreatic elastase-1 assay in patients with chronic pancreatitis. Methods: Fecal pancreatic elastase-1 was assayed in 16 patients with chronic pancreatitis. Nine healthy voluteers were studied as normal controls. We catagorized patients with chronic pancreatitis into two groups, mild/moderate (n=5) and severe (n=11), based on Cambridge grading by endoscopic retrograde cholangiopancreatography and the presence (n=7) or absence (n=9) of diabetes mellitus as a complication of chronic pancreatitis. Results: There was no difference for fecal elastase-1 between patients and controls. However, the fecal elastase-1 values in patients with severe chronic pancreatitis had a tendency to reduce than those in mild/moderate group although there was no statistically significant correlation. Furthermore, patients with diabetes mellitus as a complication of chronic pancreatitis showed lower fecal elastase-1 values, wherase those without diabetes mellitus did not. No association was found between reduced fecal elastase-1 and the etiology of chronic pancreatitis. Conclusion: Fecal elastase-1 concentrations were reduced in patients with severe chronic pancreatitis or diabetes mellitus as a complication of chronic pancreatitis.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Seung Woo(박승우) ORCID logo https://orcid.org/0000-0001-8230-964X
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Lee, Se Joon(이세준) ORCID logo https://orcid.org/0000-0002-2695-2670
Chung, Jae Bock(정재복)
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