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개의 실험적 췌외분비 부전에서 세균성 Lipase의 용량 및 제형이 장통과에 미치는 영향

Other Titles
 Effect of Doses and Formulations of Bacterial Lipase on Interstinal Transit in Canine Exocrine Pancreatic Insufficiency 
Authors
 정준표  ;  정재복  ;  이세준  ;  박효진  ;  문병수  ;  송시영  ;  이관식  ;  이상인  ;  문영명  ;  강진경 
Citation
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.35(5) : 610-620, 2000-11 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
2000-11
Keywords
Exocrine pancreatic insufficiency ; Bacterial lipase ; Intestinal transit ; Fat absorption
Abstract
Background/Aims : We determined in canine exocrine pancreatic insufficiency (EPI) when fed a high fat meal if 1) lipolytic activity as bacterial lipase (BL) alters intestinal transit (IT) dose dependently, 2) different formulations of BL have different dose responses, 3) correction of steatorrhea is related to IT. Methods : Five dogs underwent ligation of pancreatic ducts and insertion of duodenal and ileal cannulas. Perfusion and 72-hr fecal balance studies were performed while a high fat meal (fat 43%) was eaten. Powder or microtablet BL were given at doses ranging from 0 to 400×103 IU. IT of liquid and solid meal markers was evaluated by total delivery (% total amounts delivered to ileum), AUC (area under curve), T10 and T4 (minutes for 10% or 4% of ingested markers to travel from duodenum to ileum). Results : IT of the solid meal marker was not related to doses or formulations of BL. However, slowing of IT of the liquid meal marker was dose, but not formulation dependent (total delivery, p=0.0004; AUC, p=0.0017; T10, p=0.0245). Greater fat absorption was associated with slower IT of the liquid but not the solid meal marker (r2=0.262, p=0.0213). Conclusions : In dogs with EPI fed a high fat diet, slower IT of liquids is dose- but not formulation-dependent and slowing of IT of liquids correlates with greater fat absorption.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Lee, Se Joon(이세준) ORCID logo https://orcid.org/0000-0002-2695-2670
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178708
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