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급성 췌장염 환자에서 혈청 활성산소기

Other Titles
 Serum Levels of Oxygen-Derived Free Radicals in Patients with Acute Pancreatitis 
Authors
 정재복  ;  송시영  ;  강진경  ;  이진헌  ;  박윤희  ;  서정훈  ;  김혜영  ;  김경환 
Citation
 Korean Journal of Gastroenterology (대한소화기학회지), Vol.35(5) : 621-628, 2000-11 
Journal Title
 Korean Journal of Gastroenterology (대한소화기학회지) 
ISSN
 1598-9992 
Issue Date
2000-11
Keywords
Oxygen-derived free radical ; Acute pancreatitis ; Lipid peroxide
Abstract
Background/Aims : The generation of oxygen-derived free radicals has been implicated in the pathogenesis of experimental pancreatitis. The aim of this study was to determine the role of oxygen-derived free radicals in patients with acute pancreatitis. Methods : The serum levels of CRP, lipid peroxide (LPO), myeloperoxidase (MPO) and superoxide dismutase (SOD) were measured in 13 patients with acute pancreatitis and 14 healthy volunteers. Results: The serum levels of LPO and MPO were higher and the activity of SOD was lower in patients with acute pancreatitis than controls. The serum levels of LPO and MPO showed higher tendency in the patients with severe pancreatitis than in patients with mild pancreatitis. However, there was no significant difference in the serum marker of oxidative stess according to the etiology. The LPO level was especially correlated with the concentration of serum CRP and CT severity index. Conclusions: The oxygen-derived free radicals may be closely associated with inflammatory process and the severity of acute pancreatitis. Especially, the concentration of serum LPO is meaningful as an index for severity of the disease.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Song, Si Young(송시영) ORCID logo https://orcid.org/0000-0002-1417-4314
Chung, Jae Bock(정재복)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178702
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