특발성전신성간질의 임상양상

Abstract

Idiopathic generalizedepilepsy (IGE) comprises several spectrum of clinical syndromes. The pathophysiology of the IGE is not fully understood; it is evident that typical absences are the result of abnormal oscillations between the thalamus and cerebral cortex. Genetic influence may play animportant role in its development and many efforts are in progress to elucidate this. The clinical and electroencephalographic (EEG) features of the each syndrome are distinct; however, some cases are difficult to discriminate as one specific syndrome, and their clinical spectrum frequently overlaps among the syndromes. A precise diagnosis is based upon accurate interpretation of both clinical and EEG features, and will be a key-stone for best treatment strategies, for best predictor of outcome, and a strong basis for future genetic study.