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신경계의 에너지대사를 이용한 기능적 영상화

Other Titles
 Functional Imaging using Energy Metabolism of Nervous System 
Authors
 원란  ;  이배환 
Citation
 Journal of Applied Micromagnetic Energy (응용미약에너지학회지), Vol.9(1) : 6-9, 2011-06 
Journal Title
Journal of Applied Micromagnetic Energy(응용미약에너지학회지)
ISSN
 1738-4427 
Issue Date
2011-06
Keywords
2-Deoxy-glucose ; brain imaging ; energy metabolism
Abstract
In the brain, astrocytes are ideally positioned to couple synaptic activity and energy metabolism. They
possess specialized processes covering the surface of intraparenchymal capillaries. Other astrocytic processes are
wrapped around synaptic contacts that possess receptors and reuptake sites for neurotransmitters. Glutamate stimulates
glucose uptake into astrocytes and leads the glycolysis of glucose and releases lactate by astrocytes. In the aerobic
condition, lactate may be the preferred energy substrate of activated neuron. Although 2-DG and FDG may reflect
predominantly the uptake of the tracer into astrocytes and represents indirect neuronal activation, it provides a cellular
and molecular basis for functional brain imaging.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178664
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