신경계의 에너지대사를 이용한 기능적 영상화

Abstract

In the brain, astrocytes are ideally positioned to couple synaptic activity and energy metabolism. They possess specialized processes covering the surface of intraparenchymal capillaries. Other astrocytic processes are wrapped around synaptic contacts that possess receptors and reuptake sites for neurotransmitters. Glutamate stimulates glucose uptake into astrocytes and leads the glycolysis of glucose and releases lactate by astrocytes. In the aerobic condition, lactate may be the preferred energy substrate of activated neuron. Although 2-DG and FDG may reflect predominantly the uptake of the tracer into astrocytes and represents indirect neuronal activation, it provides a cellular and molecular basis for functional brain imaging.