Cited 58 times in
Relationships between circulating adiponectin levels and fat distribution in obese subjects
DC Field | Value | Language |
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dc.contributor.author | 강희철 | - |
dc.date.accessioned | 2020-08-14T03:16:11Z | - |
dc.date.available | 2020-08-14T03:16:11Z | - |
dc.date.issued | 2011-03 | - |
dc.identifier.issn | 1340-3478 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178661 | - |
dc.description.abstract | Aim: Most studies have reported that circulating levels of adiponectin are negatively correlated with the body mass index (BMI), and hypoadiponectinemia is related to cardiometabolic disorders; however, not all obese subjects have hypoadiponectinemia. The present study investigated circulating adiponectin levels and fat distribution, i.e. subcutaneous fat area (SFA) and visceral fat area (VFA), in obese subjects. Methods: Sixty-eight obese Korean subjects underwent fat distribution by computed tomography (CT) scan and laboratory tests including circulating total adiponectin levels (APN) and circulating high molecular weight adiponectin levels (HMW-APN). Results: Log-APN and log-HMW-APN did not correlate with log-BMI either in obese males or females in this study; however, log-APN significantly and negatively correlated with log-VFA both in obese males (r=-0.691, p=0.009) and females (r=-0.319, p=0.002), and log-HMW-APN also correlated negatively with log-VFA both in obese males (r=-0.650, p=0.016) and females (r=-0.370, p=0.005). Log-VFA was a significant determinant of log-APN and log-HMW-APN in obese subjects. In contrast, neither log-APN nor log-HMW-APN was significantly correlated with log-SFA in obese males and females. Conclusions: The present study demonstrated that APN and HMW-APN correlated with VFA, but not BMI and SFA, in obese subjects, and suggest that hypoadiponectinemia may represent dysfunction of adipose tissue in obesity. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Japan Atherosclerosis Society | - |
dc.relation.isPartOf | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Adiponectin / blood* | - |
dc.subject.MESH | Adipose Tissue / metabolism | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Body Composition | - |
dc.subject.MESH | Body Mass Index | - |
dc.subject.MESH | Coronary Disease / blood | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gene Expression Regulation | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Korea | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Obesity / blood* | - |
dc.subject.MESH | Tomography, X-Ray Computed / methods | - |
dc.title | Relationships between circulating adiponectin levels and fat distribution in obese subjects | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Family Medicine (가정의학교실) | - |
dc.contributor.googleauthor | Ken Kishida | - |
dc.contributor.googleauthor | Kyoung Kon Kim | - |
dc.contributor.googleauthor | Tohru Funahashi | - |
dc.contributor.googleauthor | Yuji Matsuzawa | - |
dc.contributor.googleauthor | Hee-Cheol Kang | - |
dc.contributor.googleauthor | Iichiro Shimomura | - |
dc.identifier.doi | 10.5551/jat.7625 | - |
dc.contributor.localId | A00105 | - |
dc.relation.journalcode | J01252 | - |
dc.identifier.eissn | 1880-3873 | - |
dc.identifier.pmid | 21378472 | - |
dc.contributor.alternativeName | Kang, Hee Cheol | - |
dc.contributor.affiliatedAuthor | 강희철 | - |
dc.citation.volume | 18 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 592 | - |
dc.citation.endPage | 595 | - |
dc.identifier.bibliographicCitation | JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS, Vol.18(7) : 592-595, 2011-03 | - |
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