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Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2

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dc.contributor.author박종철-
dc.date.accessioned2020-07-27T16:43:40Z-
dc.date.available2020-07-27T16:43:40Z-
dc.date.issued2016-05-
dc.identifier.issn1226-086X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/178488-
dc.description.abstractHollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfJOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleFabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Medical Engineering (의학공학교실)-
dc.contributor.googleauthorYoung-Bock Shim-
dc.contributor.googleauthorHong-Hee Jung-
dc.contributor.googleauthorJu Woong Jang-
dc.contributor.googleauthorHee Seok Yang-
dc.contributor.googleauthorHojae Bae-
dc.contributor.googleauthorJong-Chul Park-
dc.contributor.googleauthorBogyu Choi-
dc.contributor.googleauthorSoo-Hong Lee-
dc.identifier.doi10.1016/j.jiec.2016.03.014-
dc.contributor.localIdA01662-
dc.relation.journalcodeJ03016-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S1226086X1630017X#!-
dc.subject.keywordPLGA-
dc.subject.keywordHollow porous microspheres-
dc.subject.keywordSucrose-
dc.subject.keywordDexamethasone-
dc.subject.keywordBMP2-
dc.contributor.alternativeNamePark, Jong Chul-
dc.contributor.affiliatedAuthor박종철-
dc.citation.volume37-
dc.citation.startPage101-
dc.citation.endPage106-
dc.identifier.bibliographicCitationJOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, Vol.37 : 101-106, 2016-05-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers

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