Cited 12 times in
Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2
DC Field | Value | Language |
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dc.contributor.author | 박종철 | - |
dc.date.accessioned | 2020-07-27T16:43:40Z | - |
dc.date.available | 2020-07-27T16:43:40Z | - |
dc.date.issued | 2016-05 | - |
dc.identifier.issn | 1226-086X | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/178488 | - |
dc.description.abstract | Hollow porous poly(d,l-lactide-co-glycolide) microspheres (HP-PLGA-MS) were manufactured using the water-in-oil-in-water double emulsion solvent evaporation method with sucrose as a novel porogen. Dexamethasone (DEX) was dissolved in the oil phase and loaded during the preparation of the HP-PLGA-MS. Bone morphogenetic protein-2 (BMP2) with type I collagen (Col1) was incorporated into HP-PLGA-MS using a simple immersion method. The release rate of BMP2 could be controlled by the amount of Col1. DEX and BMP2 showed a sustained release profile. These results showed that the HP-PLGA-MS could be fabricated successfully using sucrose and showed great potential as a controlled dual drug delivery system. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | Fabrication of hollow porous PLGA microspheres using sucrose for controlled dual delivery of dexamethasone and BMP2 | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Medical Engineering (의학공학교실) | - |
dc.contributor.googleauthor | Young-Bock Shim | - |
dc.contributor.googleauthor | Hong-Hee Jung | - |
dc.contributor.googleauthor | Ju Woong Jang | - |
dc.contributor.googleauthor | Hee Seok Yang | - |
dc.contributor.googleauthor | Hojae Bae | - |
dc.contributor.googleauthor | Jong-Chul Park | - |
dc.contributor.googleauthor | Bogyu Choi | - |
dc.contributor.googleauthor | Soo-Hong Lee | - |
dc.identifier.doi | 10.1016/j.jiec.2016.03.014 | - |
dc.contributor.localId | A01662 | - |
dc.relation.journalcode | J03016 | - |
dc.identifier.url | https://www.sciencedirect.com/science/article/pii/S1226086X1630017X#! | - |
dc.subject.keyword | PLGA | - |
dc.subject.keyword | Hollow porous microspheres | - |
dc.subject.keyword | Sucrose | - |
dc.subject.keyword | Dexamethasone | - |
dc.subject.keyword | BMP2 | - |
dc.contributor.alternativeName | Park, Jong Chul | - |
dc.contributor.affiliatedAuthor | 박종철 | - |
dc.citation.volume | 37 | - |
dc.citation.startPage | 101 | - |
dc.citation.endPage | 106 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY, Vol.37 : 101-106, 2016-05 | - |
dc.identifier.rimsid | 64814 | - |
dc.type.rims | ART | - |
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