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Spontaneous HBsAg loss in Korean patients: relevance of viral genotypes, S gene mutations, and covalently closed circular DNA copy numbers

Authors
 Kyun-Hwan Kim  ;  Hye-Young Chang  ;  Jun Yong Park  ;  Eun-Sook Park  ;  Yong Kwang Park  ;  Kwang-Hyub Han  ;  Sang Hoon Ahn 
Citation
 CLINICAL AND MOLECULAR HEPATOLOGY, Vol.20(3) : 251-260, 2014-09 
Journal Title
 CLINICAL AND MOLECULAR HEPATOLOGY 
ISSN
 2287-2728 
Issue Date
2014-09
Keywords
HBsAg loss ; Hepatitis B virus ; Mutation ; ccc DNA
Abstract
Background/aims: Occult HBV infection can persist following HBsAg loss and be transmitted, but the virological features are not well defined. Methods: Here we investigated 25 Korean patients who lost HBsAg during follow up, either spontaneously or subsequent to therapy. Results: Whereas subtype adr (genotype C) was found in 96% of HBsAg positive patients, 75 % of patients who lost HBsAg spontaneously were seemed to be infected with the ayw subtype with sequence similar to genotype D. Mutations in the major hydrophilic region (MHR) of HBsAg were found in 7 patients who lost HBsAg spontaneously. The mutations include T123S, M125I/N, C139R, D144E, V177A, L192F, and W196L, some of which have not been reported before. Functional analysis via transfection experiments indicate that the C139R and D144E mutations drastically reduced HBsAg antigenicity, while the Y225del mutation found in one interferon-treated patient impaired HBsAg secretion. Conclusions: Lack of detectable HBsAg in patient serum could be explained by low level of ccc DNA in liver tissue, low antigenicity of the surface protein, or its secretion defect.
DOI
10.3350/cmh.2014.20.3.251
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Park, Jun Yong(박준용) ORCID logo https://orcid.org/0000-0001-6324-2224
Ahn, Sang Hoon(안상훈) ORCID logo https://orcid.org/0000-0002-3629-4624
Han, Kwang-Hyub(한광협) ORCID logo https://orcid.org/0000-0003-3960-6539
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178450
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