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Association between screening and the thyroid cancer "epidemic" in South Korea: evidence from a nationwide study

Authors
 Sohee Park  ;  Chang-Mo Oh  ;  Hyunsoon Cho  ;  Joo Young Lee  ;  Kyu-Won Jung  ;  Jae Kwan Jun  ;  Young-Joo Won  ;  Hyun-Joo Kong  ;  Kui Son Choi  ;  You Jin Lee  ;  Jin Soo Lee 
Citation
 BMJ-BRITISH MEDICAL JOURNAL, Vol.355 : i5745, 2016-11 
Journal Title
 BMJ-BRITISH MEDICAL JOURNAL 
ISSN
 0959-8138 
Issue Date
2016-11
MeSH
Carcinoma / epidemiology ; Carcinoma / pathology ; Female ; Health Surveys ; Humans ; Incidence ; Lymphatic Metastasis ; Male ; Mass Screening* ; Middle Aged ; Registries ; Republic of Korea / epidemiology ; Retrospective Studies ; Thyroid Neoplasms / epidemiology*
Abstract
Objective: To investigate whether screening for thyroid cancer led to the current "epidemic" in South Korea. Design: Review of the medical records of nationally representative samples of patients with a diagnosis of thyroid cancer in 1999, 2005, and 2008. Setting: Sample cases were randomly selected from South Korea's nationwide cancer registry, using a systematic sampling method after stratification by region. Participants: 5796 patients with thyroid cancer were included (891 in 1999, 2355 in 2005, and 2550 in 2008). Main outcome measures: The primary outcome was age standardised incidence of thyroid cancer and the changes in incidence between 1999 and 2008 according to the methods used to detect tumours (screen detection versus clinical detection versus unspecified). Results: Between 1999 and 2008, the incidence of thyroid cancer increased 6.4-fold (95% confidence interval 4.9-fold to 8.4-fold), from 6.4 (95% confidence interval 6.2 to 6.6) per 100 000 population to 40.7 (40.2 to 41.2) per 100 000 population. Of the increase, 94.4% (34.4 per 100 000 population) were for tumours less than 20 mm, which were detected mainly by screening. 97.1% of the total increase was localised and regional tumours according to the Surveillance, Epidemiology, and End Results (SEER) summary stage. Where cases were clinically detected, 99.9% of the increased incidences (6.4 per 100 000 population) over the same period were tumours less than 20 mm. Conclusion: The current "epidemic" of thyroid cancer in South Korea is due to an increase in the detection of small tumours, most likely as a result of overdetection. Concerted efforts are needed at a national level to reduce unnecessary thyroid ultrasound examinations in the asymptomatic general population.
Files in This Item:
T201606876.pdf Download
DOI
10.1136/bmj.i5745
Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Park, So Hee(박소희) ORCID logo https://orcid.org/0000-0001-8513-5163
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178448
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