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Novel Genetic Associations Between Lung Cancer and Indoor Radon Exposure

Authors
 Jung Ran Choi  ;  Sang-Baek Koh  ;  Seong Yong Park  ;  Hye Run Kim  ;  Hyojin Lee  ;  Dae Ryong Kang 
Citation
 JOURNAL OF CANCER PREVENTION, Vol.22(4) : 234-240, 2017-12 
Journal Title
 JOURNAL OF CANCER PREVENTION 
ISSN
 2288-3649 
Issue Date
2017-12
Keywords
Drive gene ; Lung cancer in never smokers ; Next generation sequencing ; Radon exposure
Abstract
Background: Lung cancer is the leading cause of cancer-related death worldwide, for which smoking is considered as the primary risk factor. The present study was conducted to determine whether genetic alterations induced by radon exposure are associated with the susceptible risk of lung cancer in never smokers. Methods: To accurately identify mutations within individual tumors, next generation sequencing was conduct for 19 pairs of lung cancer tissue. The associations of germline and somatic variations with radon exposure were visualized using OncoPrint and heatmap graphs. Bioinformatic analysis was performed using various tools. Results: Alterations in several genes were implicated in lung cancer resulting from exposure to radon indoors, namely those in epidermal growth factor receptor (EGFR), tumor protein p53 (TP53), NK2 homeobox 1 (NKX2.1), phosphatase and tensin homolog (PTEN), chromodomain helicase DNA binding protein 7 (CHD7), discoidin domain receptor tyrosine kinase 2 (DDR2), lysine methyltransferase 2C (MLL3), chromodomain helicase DNA binding protein 5 (CHD5), FAT atypical cadherin 1 (FAT1), and dual specificity phosphatase 27 (putative) (DUSP27). Conclusions: While these genes might regulate the carcinogenic pathways of radioactivity, further analysis is needed to determine whether the genes are indeed completely responsible for causing lung cancer in never smokers exposed to residential radon.
Files in This Item:
T201706026.pdf Download
DOI
10.15430/JCP.2017.22.4.234
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hye Ryun(김혜련) ORCID logo https://orcid.org/0000-0002-1842-9070
Park, Seong Yong(박성용) ORCID logo https://orcid.org/0000-0002-5180-3853
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178332
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