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Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases

Authors
 Eugene Han  ;  Yong Ho Lee 
Citation
 DIABETES & METABOLISM JOURNAL, Vol.41(6) : 430-437, 2017-12 
Journal Title
 DIABETES & METABOLISM JOURNAL 
ISSN
 2233-6079 
Issue Date
2017-12
Keywords
Arrhythmias, cardiac ; Atherosclerosis ; Diabetes mellitus ; Hypertension ; Insulin resistance ; Metabolism ; Non-alcoholic fatty liver disease ; Obesity ; Renal insufficiency ; Stroke
Abstract
As the number of individuals with non-alcoholic fatty liver disease (NAFLD) has increased, the influence of NAFLD on other metabolic diseases has been highlighted. Accumulating epidemiologic evidence indicates that NAFLD not only affects the liver but also increases the risk of extra-hepatic diseases such as type 2 diabetes mellitus, metabolic syndrome, dyslipidemia, hypertension, cardiovascular or cerebrovascular diseases, and chronic kidney disease. Non-alcoholic steatohepatitis, an advanced type of NAFLD, can aggravate these inter-organ relationships and lead to poorer outcomes. NAFLD induces insulin resistance and exacerbates systemic chronic inflammation and oxidative stress, which leads to organ dysfunction in extra-hepatic tissues. Although more research is needed to identify the pathophysiological mechanisms and causal relationship between NAFLD and cardiometabolic and renal diseases, screening for heart, brain, and kidney diseases, risk assessment for diabetes, and a multidisciplinary approach for managing these patients should be highly encouraged.
Files in This Item:
T201706066.pdf Download
DOI
10.4093/dmj.2017.41.6.430
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Han, Eu Gene(한유진)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178321
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