Cited 16 times in

Tumor Stage-Related Role of Radiotherapy in Patients with an External Auditory Canal and Middle Ear Carcinoma

Authors
 Jinhyun Choi  ;  Se-Heon Kim  ;  Yoon Woo Koh  ;  Eun Chang Choi  ;  Chang Geol Lee  ;  Ki Chang Keum 
Citation
 CANCER RESEARCH AND TREATMENT, Vol.49(1) : 178-184, 2017-01 
Journal Title
CANCER RESEARCH AND TREATMENT
ISSN
 1598-2998 
Issue Date
2017-01
MeSH
Adult ; Aged ; Carcinoma / diagnosis* ; Carcinoma / mortality ; Carcinoma / radiotherapy* ; Combined Modality Therapy ; Ear Canal / pathology* ; Ear Neoplasms / diagnosis* ; Ear Neoplasms / mortality ; Ear Neoplasms / radiotherapy* ; Ear, Middle / pathology* ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Staging ; Radiotherapy Dosage ; Retreatment ; Survival Analysis ; Treatment Failure ; Treatment Outcome
Keywords
Ear canal ; Middle ear ; Radiotherapy
Abstract
Purpose: The purpose of this study was to evaluate the clinical outcomes of patients treated with radiotherapy (RT) for a carcinoma of the external auditory canal (EAC) and middle ear.

Materials and methods: The records of 32 patients who received RT from 1990 to 2013 were reviewed retrospectively. The Pittsburgh classification was used to stage all the cancers (early stage, T1/T2 [n=12]; advanced stage, T3/T4 or N positive [n=20]). Twenty-one patients (65.6%) were treated with postoperative RT and 11 patients (34.4%) were treated with definitive RT. The median radiation doses for postoperative and definitive RT were 60 Gy and 64.8 Gy, respectively. Chemotherapy was administered to seven patients (21.9%).

Results: The 5-year overall survival and disease-free survival rates for all patients were 57% and 52%, respectively. The disease control rates for the patients with early stage versus advanced stage carcinomawere 55.6% (5/9) and 50% (6/12) in the postoperative RT group and 66.7% (2/3) and 37.5% (3/8) in the definitive RT group, respectively. Overall, 15 cases (14 patients, 46.7%) experienced treatment failure; these failures were classified as local in four cases, regional in one case, and distant in 10 cases. The median follow-up period after RT was 51 months (range, 7 to 286 months).

Conclusion: Patients with early stage carcinoma achieved better outcomes when definitive RT was used. Advanced stage carcinoma patients experienced better outcomes with postoperative RT. The high rate of distant failure after RT, with or without surgery, reflected the lack of a consensus regarding the best therapeutic approach for treating carcinoma of the EAC and middle ear.
Files in This Item:
T201706174.pdf Download
DOI
10.4143/crt.2016.165
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
Yonsei Authors
Koh, Yoon Woo(고윤우)
Keum, Ki Chang(금기창) ORCID logo https://orcid.org/0000-0003-4123-7998
Kim, Se Heon(김세헌)
Lee, Chang Geol(이창걸) ORCID logo https://orcid.org/0000-0002-8702-881X
Choi, Eun Chang(최은창)
Choi, Jinhyun(최진현)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178315
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links