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유전역학적 연구방법: 유전자 분리모형 분석

Other Titles
 Segregation Analysis in Genetic Epidemiology 
Authors
 지선하 
Citation
 Korean Journal of Epidemiology (한국역학회지), Vol.19(2) : 95-102, 1997 
Journal Title
 Korean Journal of Epidemiology (한국역학회지) 
ISSN
 1225-3596 
Issue Date
1997
Abstract
Genetic epidemiology is an emerging field with diverse interests, one that represents an important interaction between the two parent disciplines: genetics and epidemiology. Segregation analysis was originally designed to test whether or not an observed mixture of phenotypes among offspring is compatible with Mendelian inheritance. Over the years, segregation analysis has broadened to encompass, but the ultimate goal is the same: to test for compatibility with Mendelian expectations by estimating parameters of a given model of inheritance. Segregation analysis tests explicit models of inheritance on family data. The analytic strategy relies heavily on fitting genetic models, along with a few arbitrary nongenetic models, and selecting the model that best explains the data. While showing an adequate fit to a genetic model of inheritance in a single data set does not constitute proof that a trait or disease is in truth under genetic control, it may be considered strong statistical evidence. Even though segregation analysis has its limitations, it remains a powerful tool for identifying genetic mechanisms that may control traits associated with disease or contribute to disease risk.
Files in This Item:
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Appears in Collections:
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Jee, Sun Ha(지선하) ORCID logo https://orcid.org/0000-0001-9519-3068
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/178074
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