1137 546

Cited 0 times in

심방세동 환자에서 항부정맥제 Ic drug인 Propafenone과 Flecainide의 drug Efficacy

Other Titles
 Comparision of the Efficacy of Propafenone and Flecainide in Patients with Atrial Fibrillation 
Authors
 김동수  ;  고충원  ;  조홍근  ;  김태용  ;  안신기  ;  이문형  ;  김성순 
Citation
 Korean Circulation Journal (순환기), Vol.27(9) : 860-866, 1997 
Journal Title
KOREAN CIRCULATION JOURNAL(순환기)
ISSN
 1738-5520 
Issue Date
1997
Abstract
Background:Atrial fibrillation is one of the most common cardiac arrhythmias which has been
received relatively little attention until recently. Despite the variety of treatment modalities including
drugs, surgery, catheter ablation and devices, the overall treatment of atrial fibrillation is not always
satisfactory. Pharmacotherapy is still the most commonly used treatment though the unfavorable side
effects of antiarrhythmic drugs are problematic. The purpose of this study is to compare the efficacy
of class Ic antiarrhythmic drugs, propafenone versus flecainide.
Methods:We treated one hundred eighteen patients with atrial fibrillation by class Ic
antiarrhythmic durgs, propafenone or flecainide with/without DC cardioversion to convert to and
maintain the sinus rhythm. We compared the clinical findings, drug efficacy, side effects of durgs
between two groups.
Results:30 patients were treated by propafenone and 88 patients by flecainide. 21 and 60 patients in
each group were lone atrial fibrillation, 14 and 49 patients were paroxysmal atrial fibrillation. Mean
duration of drug administration were 360.9, 339.4 days, respectively. The convesion rate to sinus
rhythm by drugs was 25.0% in propafenone group and 30.7% in flecainide group(p=NS). The 300
days-manitenance rates of sinus rhythm after conversion by drugs or DC cardioversion were 63.3%,
70.4%(p=NS)respectively.
The side effects of durgs were dizziness, nausea and vomitting in both group and 1st degree AV
block, transient sinus node dysfunction and decreased visual acuity in flecainde group. The drugs
were discontinued in 11(37.7%) and 26(29.5%) patients in each group due to recurrence of atrial
fibrillation or side effects of drugs.
Conclusion:This study suggests that propafenone and flecainide are comparably effective in
- 861 -
maintaining sinus rhythm in atrial fibrillation patients. Further prospective and large study is required
to confirm this findings.
Files in This Item:
T199701587.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Shin Ki(안신기) ORCID logo https://orcid.org/0000-0002-9822-7961
Lee, Moon-Hyoung(이문형) ORCID logo https://orcid.org/0000-0002-7268-0741
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177998
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links