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Dapsone투여로 유발된 methemoglobin 혈증에서 N-acetylcysteine 의 효과

DC FieldValueLanguage
dc.contributor.author김승호-
dc.date.accessioned2020-07-03T17:45:08Z-
dc.date.available2020-07-03T17:45:08Z-
dc.date.issued1997-
dc.identifier.issn1226-4334-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/177794-
dc.description.abstractBackground To determine whether N-acetylcysteine(NAC) reduces methemoglobin. Method: We carried out an in vivo experiment in rats, weighed about 300g. Each rat was ingested 200mg of dapsone(4,4` diaminodiphenyl sulphone) to induce methemoglobinemia. After 1 hour, 30 rats were received NAC 160mg(2ml) and another 30 rats, served as control, were received 2ml of normal saline orally, 4 times hourly. Serum methemoglobin concentrations were checked 1,6, and 24 hours after dapsone ingestion. Result: The methemoglobin concentrations on each time were 27.1±5.8%, 235±8.8%, 17.1±6.4%(mean±SD) in control group and 25.5±6.3%, 25.5±8.8%, 65.5±31.2%(mean±SD) in NAC group. There were no difference on methemoglobin concentrations at 1 and 6 hours between two groups(P>.05). At 24 hours, the methemoglobin concentrations of NAC group was significantly higher than those of control group(P<.01). Conclusion: NAC had no therapeutic effects on dapsone induced methemoglobinemia in this experimental setting.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisher대한응급의학회-
dc.relation.isPartOfJournal of the Korean Society of Emergency Medicine (대한응급의학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.titleDapsone투여로 유발된 methemoglobin 혈증에서 N-acetylcysteine 의 효과-
dc.title.alternativeEffect of N-acetylcysteine on Dapsone-Induced Methemoglobinemia-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine (의과대학)-
dc.contributor.departmentDept. of Emergency Medicine (응급의학교실)-
dc.contributor.googleauthor장문준-
dc.contributor.googleauthor김승호-
dc.contributor.googleauthor이한식-
dc.contributor.localIdA00667-
dc.relation.journalcodeJ01868-
dc.contributor.alternativeNameKim, Seung Ho-
dc.contributor.affiliatedAuthor김승호-
dc.citation.volume8-
dc.citation.number2-
dc.citation.startPage15-
dc.citation.endPage19-
dc.identifier.bibliographicCitationJournal of the Korean Society of Emergency Medicine (대한응급의학회지), Vol.8(2) : 15-19, 1997-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers

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