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Effects of Growth Factors in rabbit's flexor tendon culture

 Ho Jung Kang  ;  Jin Woo Lee  ;  Soo Bong Hahn  ;  Eung Shick Kang 
 Journal of the Korean Society for Surgery of the Hand (대한수부외과학회지), Vol.2(2) : 387-393, 1997 
Journal Title
 Journal of the Korean Society for Surgery of the Hand (대한수부외과학회지) 
Issue Date
tendon culture, Growth factors(IGF, EGF, FGF, PDGF)
Growth factors have the ability to stimulate matrix synthesis and cell proliferation in rabbit flexor tendon. Maximal stimulation effects of growth factors have a wide variation. It depends upon the different anatomic site of tendon segment, kinds of growth factor, concentration of growth factors and time sequence. Since proliferation was an early component of intrinsic tendon healing, we investigated the short-term dose response to four different growth factors on in vitro rabbits tendon culture. We evaluated the various concentration effects of recombinant human insulin-like growth factor l(IGF), recombinant human epidermal growth factor(EGF), fibroblast growth factor(FGF), recombinant human plate-derived growth factor-BB(PDGF). Fetal calf serum was the most potent stimulator of cell proliferation and protein synthesis in vitro rabbits tendon culture. Matrix synthesis and cell proliferation were stimulated dose-dependently by IGF at doses between 50 and 150 ng/ml. The maximum mitogenic effect of EGF was observed at the concentration at 100ng/ml.(1.3 times over the media only culture control). The rabbits tendon was significantly dose-dependently responded to PDGF, whereas there was no significant response to FGF.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Orthopedic Surgery (정형외과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Ho Jung(강호정) ORCID logo https://orcid.org/0000-0003-0273-1264
Kim, Hak Sun(김학선) ORCID logo https://orcid.org/0000-0002-8330-4688
Lee, Jin Woo(이진우) ORCID logo https://orcid.org/0000-0002-0293-9017
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