장관 Behcet 병의 임상적 고찰 및 Sulfasalazine의 치료효과

Abstract

Background/Aims: Intestinal Behcet disease often has a serious course, and a high frequency of perforation and hemorrhage has been reported. The standard treatment for this disease has not been settled. Methods: For the understanding of the clinical features of intestinal Behcet disease and the therapeutic effects of sulfasalazine, 31 patients with Behcet disease who were admitted to the Yonsei University Medical College Hospital from 1981 to 1993 were reviewed. Results: The mean age wos 35.5 years and the ratio of male to female was 1.8:1. The main clinical symptoms were abdorninal pain, bloody stool, and diarrhea. The intestinal lesions were most comrnonly found in the ileoceca] region(84%) and the most common lesions were discrete ulcers(94%). The localized distribution(81%) of ulcers was rnore prevalent than the diffuse form and the incidence of a single ulcer was similar to that of multiple ulcers. Operation were performed in 13 cases and the indications of operation were peritonitis(3 cases), persisted abdominal pain(2 cases), fistula t'ormation(J case), intestinal obstruction(1 case), massive bleeding(1 case), and obscure diagnosis(S cases). Steroid and colchicine were used in 22 cases and sulfasalazine in 14 cases. Symptomatic or colonoscopic improvernent was more frequent in sulfasalazine(79%) than steroid & colchicine(36%). Conclusions: Intestinal Beh