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저산소/재산소화와 Sodium Nitroprusside가 분리 위선세포의 산분비 및 세포내 Cyclic Nucleotide에 미치는 영향
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2020-07-03T17:36:10Z | - |
dc.date.available | 2020-07-03T17:36:10Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177687 | - |
dc.description.abstract | Background/Aims: Ischemia/reperfusion is associated with mucosal injury in trauma, rnajor surgery, and nonsteroidal anti-inflammatory drug administration. Nitric oxide and cyclic nucleotides appear to play a cytoprotective role against gastric mucosal injury. Present study was aimed to investigate a cytoprotective mechanism of gastric cells against hypoxia/reoxygenation. Methods: lsolated gastric cells treated with or without sodium nitroprusside were exposed to hypoxia(30min) /reoxygenation(lh). Histamine(]0'M) with 3-isobuty]-1-methylxanthine(10'M) was used to stimulate acid secretion. Acid secretory activity was measured by [ C]-aminopyrine accumulation ratio. The intracellular cGMP and cAMP were deterrnined by radioimmunoassay. The cell viability was assessed by lactic dehydrogenase release and trypan blue exclusion test. Results: Hypoxia/ reoxygenation inhibited acid secretion, but increased intracellular levels of cGMP and cAMP. Sodium nitroprusside inhibited acid secretion stimulated by histamine and 3-isobutyl- 1-methylxanthine. cGMP level, but not cAMP level, of gastric cells was increased by sodium nitroprusside. Cell viability was neither affected by hypoxia/reoxygenation nor sodium nitroprusside. Conclusions: Hypoxia/reoxygenation increases cGMP and inhibits acid secretion, possibly through nitric oxide induction, which acts as a mucosal defense mechanism. Increase of cellular cAMP during hypoxic exposure is thought of as cellular adaptation, and this is not re]ated to acid secretion. (Korean J Gastroenterol 1997;29:164-174) | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean Journal of Gastroenterology | - |
dc.publisher | Korean Journal of Gastroenterology | - |
dc.relation.isPartOf | Korean Journal of Gastroenterology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.title | 저산소/재산소화와 Sodium Nitroprusside가 분리 위선세포의 산분비 및 세포내 Cyclic Nucleotide에 미치는 영향 | - |
dc.title.alternative | Effects of Hypoxia/Reoxygenation and Sodium Nitroprusside on Acid Secretion and Cyclic Nucleotide of Isolated Gastric Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | 김혜영 | - |
dc.contributor.googleauthor | 이송철 | - |
dc.contributor.googleauthor | 김경환 | - |
dc.contributor.localId | A00311 | - |
dc.relation.journalcode | J02015 | - |
dc.identifier.eissn | 2233-6869 | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.citation.volume | 29 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 164 | - |
dc.citation.endPage | 174 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gastroenterology, Vol.29(2) : 164-174, 1997 | - |
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