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흰쥐 피부를 이용한 벤지딘의 피부 투과에 대한 연구

Other Titles
 In Vitro Study of Skin Penetration of Benzidine Using Excised Rat Skin 
Authors
 이지현  ;  염혜경  ;  김치년  ;  송재석  ;  원종욱  ;  노재훈 
Citation
 Korean Journal of Occupational and Environmental Medicine (대한산업의학회지), Vol.9(3) : 430-438, 1997 
Journal Title
 Korean Journal of Occupational and Environmental Medicine (대한산업의학회지) 
ISSN
 1225-3618 
Issue Date
1997
Abstract
Although major route of absorption for benzidine and benzidine dihydrochloride are known to be skin, the skin penetration rates for benzidine and benzidine dihydrochloride are not known well at all. In order to provide basic data on effective management for worker's health and workplace environment, we used the skin of Sprague Dawley rat to obtain the skin penetration rates for benzidine and benzidine dihydrochloride, and studied the possibility of the skin penetration for Direct Black 38. The penetration rates of benzidine at 250, 500 and 1000㎍/㎖ were 15.57㎍/Hr/㎤(84.49 nmole/hr/㎤), 29.47 ㎍/hr/㎤ (159.96nmole/hr㎤), and 47.12 ㎍/hr/㎤ (255.77nmole/hr/㎤) respectively. The penetration rates of benzidine showed a concentration dependent increase, and from 22.92 to 30.76% of total benzidive penetrated within 12 hours. The penetration rates of benzidine dihydrochloride at 250, 500, 1000㎍/㎖ were 8.92 ㎍/hr/㎤ (20.22 nmole/hr/㎤), 9.64 ㎍/hr/㎤(21.85 nmole/hr/㎤), and 10.22 ㎍/hr/㎤ (23.15 nmole/hr/㎤) respectively. The penetration rates of benzidine dihydrochloride did not show a concentration dependent increase as show in benzidine. Because benzidine is more lipid soluble but benzidine dihydrochloride is more water soluble, benzidine is absorbed more rapidly than benzidine dihydrochloride. The reduction of benzidine dyes to benzidine has been known to be possible in an anaerobic condition only. The skin penetration of benzidine dye might be impossible because of the aerobic nature of skin. Further studies on the possibility of skin penetration of benzidine dye be needed.
Full Text
http://www.dbpia.co.kr/journal/articleDetail?nodeId=NODE01155926&language=ko_KR
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Roh, Jae Hoon(노재훈)
Won, Jong Uk(원종욱) ORCID logo https://orcid.org/0000-0002-9200-3297
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177657
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