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과배란유도 성숙난포액내의 Insulin-like Growth Factor-I ( IGF-I ) , Insulin-like Growth Factor Binding Protein-3 ( IGFBP-3 ) , Growth Hormone ( GH ) 및 Estradiol ( E2 ) 과의 상호관계

Other Titles
 Correlations amongst Insulin-like Growth Factor-I , Insulin-like Growth Factor Binding Protein-3 , Growth Hormone and Estradiol in Follicular Fluid of the Patients with Ovulation Induction 
 이용주  ;  배상욱  ;  정창진  ;  김동현  ;  장경환  ;  이병석  ;  박기현  ;  조동제  ;  송찬호 
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지), Vol.40(3) : 606-613, 1997 
Journal Title
 Korean Journal of Obstetrics and Gynecology (대한산부인과학회잡지) 
Issue Date
Recently, the ovary is known to be a center of paracrine and autocrine rehulating factors. IGF-I is a local regulator of follicular function and a poten stimulator of ovarian cell proliferation and differentiation, in synergy will the gonadotrophins, whilst GH may exert its effect by changing intra-ovarian IGF-I concentration. Inbiological fluids, IGFs are bound to specific, high affinity binding proteins(IGFBP). The IGFBPs are considered paracrine modulators of the action of IGF-I in the ovary. The aim of the study is to elucidate relationships amongst IGF-I, IGFBP-3, GH and estadiol in mature follicular fluids or serum. Thirty-six infertility patients who underwent ovulation induction program by GnRH agonist short or long protocol for in vitro fertilization (IVF) were examined to investigate the correlations amongst the concentration of IGF-I, IGFBP-3, GH and estradiol in follicular fluid or serum. These hormones were quantitatively anayzed by radioimmunoassay(RIA) or Immunoradiometric assay(IRMA). There were statistically significant correlations between the concentration of IGF-I and GH, IGFBP-3 in follicular fluid. Therefore, GH tends to increase IGF-I levels in follicular fluid and IGF-I may functions as an important regulator of IGFBP-3 synthesis in follicular fluid, but IGFBP-3 is not likely to be under the direct control of GH in follicular fluid.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Obstetrics and Gynecology (산부인과학교실) > 1. Journal Papers
Yonsei Authors
Bai, Sang Wook(배상욱) ORCID logo https://orcid.org/0000-0001-7724-7552
Lee, Byung Seok(이병석) ORCID logo https://orcid.org/0000-0001-6001-2079
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