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인체 방광상피세포암에서의 Telomerase Activity

Other Titles
 Telomerase Activity in Transitional Cell Carcinoma of Bladder 
Authors
 이동현  ;  양승철  ;  홍성준  ;  정병하  ;  정윤형 
Citation
 Korean Journal of Urology (대한비뇨기과학회지), Vol.38(11) : 1147-1150, 1997 
Journal Title
 Korean Journal of Urology (대한비뇨기과학회지) 
ISSN
 0494-4747 
Issue Date
1997
Abstract
Telomeres are the specialized structures at the end of all eukaryotic chromosomes that are thought to give important functions in protecting genomic DNA from degradation and deleterious recombination events. The enzyme telomerase maintains a constant telomere length observed in immortalized cells, allowing unlimited cell proliferation. Various cancer cells express telomerase activity. We analyzed telomerase activity in bladder tumors and normal tissues. Bladder tumor tissues and normal mucosa of 25 patients were obtained during transurethral resection of bladder (TURB) or after radical cystectomy. Telomerase activity was analyzed using telomeric repeat amplification protocol (TRAP) assay which is based on polymerase chain reaction (PCR) technique. Twenty-three of 25 bladder tumor tissue were transitional cell carcinomas and remains were urothelial hyperplasia and inverted papilloma, respectively. We observed telomerase activity in 22 of 23 bladder cancer tissues (95.7%); only one did not express telomerase activity. Telomerase activity was not detected in all normal tissues except one, which was obtained from a patient with carcinoma in situ. Urothelial hyperplasia and inverted papilloma did not express telomerase activity. Our data demonstrates that the majority of human bladder cancers obtained from patients with transitional cell carcinoma expressed telomerase activity whereas urothelial hyperplasia and inverted papilloma did not. It indicates that telomerase activity may be a important role in carcinogenesis.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Chung, Byung Ha(정병하) ORCID logo https://orcid.org/0000-0001-9817-3660
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177622
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