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Reversibility of Ultrastructural Changes of Cultured Human Nasal Epithelial Cells Induced by Tumor Necrosis Factor-α

 Kyung Su Kim  ;  Jeung Gweon Lee  ;  Sung-Shik Kim  ;  Kuk Jin Park  ;  Joo-Heon Yoon 
 Journal of Rhinology, Vol.4(1) : 50-56, 1997 
Journal Title
 Journal of Rhinology 
Issue Date
Tumor necrosis factor (TNF)-α can induce ultrastructural changes in cultured human nasal epithelial cells. The aims of this study are to determine the recovery time from the changes induced by TNF-α and observe whether various degrees of changes will result in a complete return to normal status. The recovery of cilia was observed on the third day after cessation of adding TNF-α and the normalization of secretory cell area was observed on the fifth day. The morphologic changes induced by TNF-α were reversible except with the concentration of 100 ng/ml. The results suggest that the ultrastructural changes induced by TNF-α are mostly reversible and that this reversibility corresponds with the in vivo state.
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1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Yoon, Joo Heon(윤주헌)
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