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공터키안 증후군의 임상적 및 내분비학적 고찰

Other Titles
 Primary empty sella syndrome 
 김은숙  ;  김인재  ;  문윤재  ;  나상규  ;  남수연  ;  이은직  ;  김경래  ;  송영득  ;  임승길  ;  이현철  ;  허갈범 
 Endocrinology and Metabolism (대한내분비학회지), Vol.12(3) : 386-392, 1997 
Journal Title
 Endocrinology and Metabolism (대한내분비학회지) 
Issue Date
Backbround: Primary empty sella syndrome(PES) is thought to arise from an incompetent diaphragma allowing progressive herniation of arachnoid membrane with secondary compression and atrophy of the pituitary gland. As a consequence of the improvement and widespread use of neuroradiological techniques, such as computerized tomography(CT) and magnetic resonance imaging(MRI), empty sella is more frequently disclosed. The aim of this study is to assess the associated clinical characteristics and endocrinologic disturbance in empty sella syndrome. Methods: From January 1986 to June 1996, 171 patients with empty sella syndrome have undergone analysis for clinical characteristics and associated disease. Result: In our study, PES was diagnosed in 131 of the 171 patients(77%). Primary empty sella syndrome was frequent in middle aged women(female:male 115:16, mean age: 50.6+12.6 years). The common clinical features were headache(80.2%), obesity(72.5%), and hypertension(27.5%). Most of patients with PES have normal pituitary function(75%). The frequent pituitary dysfunction was hyperprolactinemia in PES(21%). Partial and total emptiness of sella on sella CT or MRI were in 111(84.7%) patients, and in 20(15.4%) patients, respectively. The most common associated disease with empty sella syndrome was pituitary adenoma. Conclusion: PES should be considered as a possible cause in obese middle aged women with unexplained headache. The combined pituitary function test should be considered for evaluation of pituitary dysfunction when clinically suspected. (J Kor Soc Endocrinol 12:386-392, 1997)
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hyun Chul(이현철)
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