Recently, the new technique that allows the in vivo visualization in man of the somatostatin receptor positive tumor after iv adminstration of the 123I-coupled somatostatin analogue Tyr-octreotide (somatostatin receptor scan) was developed. We have experienced a forty eight-year-old female patient with acromegaly and multiple thyroid nodules. Somatostatin receptor scan was performed. Unexpectedly, both pituitary tumor and multiple thyroid nodules were presented with positive by somatostatin receptor scan and we thought that multiple thyroid nodules might be malignancy, probably medullary thyroid carcinoma. Therefore, bilateral subtotal thyroidectomy was performed and pathologic finding showed thyroid follicular adenoma.