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인슐린비의존형 당뇨병 환자에서 미세 및 대혈관 합병증에 따른 안지오텐신 1 전환 효소 유전자의 다형성

Other Titles
 ngiotensin 1 Converting Enzyme ( ACE ) Gene Polymorphism According to Micro - and Mocro - angiopathy in non - insulin Dependent Diabetes Mellitus 
 남문석  ;  이현철  ;  이지현  ;  차봉수  ;  남수연  ;  송영득  ;  임승길  ;  김경래  ;  허갑범 
 Journal of Korean Diabetes Association (당뇨병), Vol.21(4) : 397-405, 1997 
Journal Title
 Journal of Korean Diabetes Association (당뇨병) 
Issue Date
Background: Chronic micro- and macro-angio- pathy in diabetes are clinically significant complications that affect both quality and length of life in diabetic patients. Angiotensin 1 converting enzyme (ACE) is of key importance in regulating systemic and renal circulation by converting angiotensin-1 into -2 and inactivating bradykinin, Recent reports suggest that the ACE gene polymorphism is associated with susceptibility to micro- and macro-angiopathy in diabetes. But the results are diffetent according to the type of diabetes and complication. Methods: We investigated the alleles of the ACE gene and measured the ACE activity in the 169 cases of non-insulin dependent diabetic patients and in the 95 cases of controls matched with age and BMI. Results: The measured ACE activity was well correlated with the count of D allele. We found no differences of ACE alleles between in diabetes and control. No association was found between ACE gene polymorphism and diabetic microangiopathy(retinopathy or nephropathy). But DD genotypes (homozy- gotes for the deletion polymorphism) and D allele were found more frequently in diabetic patients with coronary artery obstructive diseases than in patients without coronary artery obstructive diseases in coronary angiography. Conclusion: These data indicate that ACE gene polymorphism in non-insulin dependent diabetes is associated with coronary artery obstructive diseases, but not with chronic microangiopathy.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hyun Chul(이현철)
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