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인슐린비의존형 당뇨병 환자에서의 β3 - adrenergic 수용체 유전자 다형성

Other Titles
 The β3 - adrenergic Receptor Gene Polymorphism in Non - Insulin Dependent Diabetes Mellitus 
 이지현  ;  이해일  ;  이상원  ;  남수연  ;  원영준  ;  차봉수  ;  남문석  ;  송영득  ;  이은직  ;  임승길  ;  김경래  ;  이현철  ;  허갑범 
 Journal of Korean Diabetes Association (당뇨병), Vol.21(2) : 130-137, 1997 
Journal Title
 Journal of Korean Diabetes Association (당뇨병) 
Issue Date
Background: The B3-adrenergic receptor, located mainly in adipose tissue, is known to be involved in the regulation of lipolysis and thermogenesis. Recently studies have shown that the B3-adrenergic receptor gene polymorphism is associated with Non-Insulin Dependent Diabetes Mellitus(NIDDM) and insulin resistance. We investigated the relationship between the B3-adrenergic receptor gene polymorphism and the cli!ical and biochemical features of NIDDM patients. Methods: Anthropometeric and biochemi al characteristics were determined for 134 NIDDM subjects and 30 nondiabetic controls. All subjects were genotyped for the 0-adrenergic receptor gene mutation using restriction fragment length polymorphism assay. Results: The allelic frequency of the mutated allele was similar in NIDDM subjects and nondiabetic controls(11%, 12% respectively). There was no difference in the Arg64 allelic frequency of the B3-adrenergic receptor gene according to the onset age of diabetes. In diabetic group, the clinical and biochemical characteristics were not statistically different between the B3-adrenergic receptor gene mutation and nonmutation group. In control group, also no clinical differences were found between mutation and non- mutation group. When comparing frequency of obesity according to the B3-adrenergic receptor gene mutation in diabetic patients, we did not find the difference between the two groups. Conclusion: These results suggest that the b3-adrenergic receptor gene is not a major determinant for the development of obesity and NIDDM in Korea.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Hyun Chul(이현철)
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