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제주도 주민에서 Human T-cell Lymphotropic Virus Type I(HTLV-I) 감염에 관한 혈청역학적 연구

Other Titles
 The Seroepidemiologic Study for Human T-cell Lymphotropic Virus Type I(HTLV-I) Infection in Residents of Cheju-Do 
Authors
 김준명  ;  김웅  ;  최창현  ;  강석민  ;  김원천  ;  윤태영  ;  최중명  ;  박순영  ;  유동준 
Citation
 Korean Journal of Infectious Diseases (감염), Vol.29(3) : 171-181, 1997 
Journal Title
 Korean Journal of Infectious Diseases (감염) 
ISSN
 0368-6221 
Issue Date
1997
Abstract
Background : Human T-cell lymphotropic virus type I(HTLV-I) is a retrovirus that has been identified as a cause of adult T-cell leukemia/lymphoma and tropical spastic paraparesis. HTLV-I infection is highly endemic in the southwestern islands of Japan, Caribbean basin, South America, and Africa. In 1993, we showed that the seroprevalence of antibodies to HTLV-I was 0.13% among blood donors in Korea, but surprisingly, 0.80% in Cheju-Do adjacent to endemic areas of Japan. So this study was designed to reevaluate the seroprevalence of antibodies to HTLV-I among residents in Cheju-Do. Methods : 1 Total 2,372 residents in Cheju-Do were tested from December, 1995 to March, 1996. Anti-HTLV-I antibodies were detected by the microtiter particle agglutination test. Results : Among total 2,372 residents, 19 were anti-HTLV-I positive. So the overall positive rate of anti-HTLV-I antibodies was 0.80%. The Positive rate in females was higher than in males(0.82% vs 0.78%). The positive rate was 1.45% in the age group of 20-29 years, 1.41% in 40-B9 years, 0.91% in 0-9 years, 0.70% in 30-39 years, and 0.54% in 50-59 years. The mean age of seropositives is 35.2 in males and 35.4 in females, with a mean of 35.3. Geographically, high Positive rate was observed in Sogwipo-City(1.37%) and Namcheju-Gun(0.83%) compared to those of Pukcheju-Gun(0.64%) and Cheju-City(0.61%), which showed high seroprevalence in districts adjacent to endemic areas of Japan. Any specific risk factors or associated disorders of HTLV-I infection could not be found among the seropositives. Conclusion : The seroprevalence of antibodies to HTLV-I in Cheju-Do was noted to be very high by the microtiter particle agglutination test. So henceforth serosurvey by confirmative laboratory tests is needed, and if high seroprevalence is showed from it, screening of blood donors for HTLV-I in Cheju-Do should be considered to prevent transfusion-associated HTLV-I infection.
Files in This Item:
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, June Myung(김준명)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177469
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