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Large Cerebral Infarction During Praziquantel Therapy in Neurocysticercosis

Authors
 Oh Young Bang  ;  Ji Hoe Heo  ;  Sun Ah Choi  ;  Dong Ik Kim 
Citation
 STROKE, Vol.28(1) : 211-213, 1997 
Journal Title
 STROKE 
ISSN
 0039-2499 
Issue Date
1997
MeSH
Antiplatyhelmintic Agents/adverse effects* ; Basal Ganglia/diagnostic imaging ; Brain Diseases/drug therapy ; Brain Diseases/parasitology* ; Brain Diseases/physiopathology ; Carotid Artery, Internal/diagnostic imaging ; Cerebral Angiography ; Cerebral Infarction/diagnosis ; Cerebral Infarction/etiology* ; Cysticercosis/drug therapy* ; Cysticercosis/physiopathology ; Humans ; Inflammation ; Magnetic Resonance Imaging ; Male ; Mesencephalon/pathology ; Middle Aged ; Parietal Lobe/diagnostic imaging ; Praziquantel/adverse effects* ; Tomography, X-Ray Computed
Abstract
BACKGROUND: Large cerebral infarction is a rare complication of neurocysticercosis. Endarteritis by inflammation of the leptomeninges is known to be its cause. CASE DESCRIPTION: A 59-year-old man with known neurocysticercosis developed a large cerebral infarction during praziquantel therapy. A follow-up MRI obtained immediately after his cerebral infarction demonstrated notable decrease in the size of the cysts and more prominent enhancement around the peripheral margins of the cysts and the major vessels in comparison with the initial MRI. Cerebral angiography disclosed occlusions and narrowing of both internal carotid arteries at the supraclinoid portions, where multiple cysts were found on the MRI. CONCLUSIONS: Findings in our patient strongly suggest that a secondary inflammation reaction caused by the destruction of the cysts might have enhanced the process of endarteritis. The possible deleterious effects of praziquantel therapy should be considered in the treatment of patients with subarachnoid cysticerci.
Full Text
https://www.ahajournals.org/doi/full/10.1161/01.str.28.1.211?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%3dpubmed
DOI
10.1161/01.str.28.1.211
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Heo, Ji Hoe(허지회) ORCID logo https://orcid.org/0000-0001-9898-3321
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177407
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