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Evidence for Selection of 11 Amino Acid CDR3 Domains in VKIII-derived Immunoglobulin Light Chains in Kawasaki Disease

Authors
 D. S. Kim  ;  B. H. Han  ;  S. K. Lee  ;  H. K. Lee  ;  Y. J. Chwae  ;  K. Y. Lee 
Citation
 SCANDINAVIAN JOURNAL OF RHEUMATOLOGY, Vol.26(5) : 350-354, 1997 
Journal Title
 SCANDINAVIAN JOURNAL OF RHEUMATOLOGY 
ISSN
 0300-9742 
Issue Date
1997
MeSH
Acute Disease ; Amino Acids ; B-Lymphocytes/immunology ; Child, Preschool ; Genes, Immunoglobulin/genetics ; Humans ; Immunoglobulin Variable Region/genetics ; Immunoglobulin Variable Region/immunology* ; Immunoglobulin kappa-Chains/genetics ; Immunoglobulin kappa-Chains/immunology* ; Infant ; Mucocutaneous Lymph Node Syndrome/genetics ; Mucocutaneous Lymph Node Syndrome/immunology* ; Oligonucleotide Probes/chemistry ; Polymerase Chain Reaction
Abstract
Kawasaki disease (KD) is a rheumatic disease that occurs during childhood. Although T cells have been implicated as having an important role in the pathogenesis of KD, the role of B cells is unclear. To detect preferential expression of 11 amino acid complementarity determining region (CDR)3 domains, we used two-stage PCR (polymerase chain reaction) to analyze the CDR3 lengths of VkIII-derived immunoglobulin kappa light chains expressed in peripheral blood B cells during the acute, subacute, and convalescent phase of this disease. As controls, the peripheral blood B cells of age-matched normal and children with acute febrile diseases other than KD were tested. In 5 of 7 KD patients, expression of kappa light chains containing 11 amino acid codon CDR3 intervals was increased during the acute and subacute phase of KD but decreased during the convalescent phase. Two of the 7 KD patients showed the same pattern during the subacute and convalescent phase, but not during the acute phase. Two of the 5 patients with acute febrile diseases other than KD showed increased expression of kappa chains with 11 amino acid codon CDR3 intervals, but it was not a major fraction. Three of the 5 patients with acute febrile diseases other than KD and all normal control subjects showed only 9 and 10 amino acid CDR3 domains. These results strongly suggest that B cells expressing kappa light chains with the 11 amino acid CDR3 domains might be involved in the pathogenesis of KD.
Full Text
https://www.tandfonline.com/doi/abs/10.3109/03009749709065697
DOI
10.3109/03009749709065697
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Soo(김동수)
Lee, Soo Kon(이수곤)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177405
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