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Actual half-life of alpha-fetoprotein as a prognostic tool in pediatric malignant tumors

Authors
 Han SJ  ;  Yoo S  ;  Choi SH  ;  Hwang EH 
Citation
 PEDIATRIC SURGERY INTERNATIONAL, Vol.12(8) : 599-602, 1997 
Journal Title
 PEDIATRIC SURGERY INTERNATIONAL 
ISSN
 0179-0358 
Issue Date
1997
MeSH
Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Biomarkers, Tumor/blood ; Child ; Child, Preschool ; Disease Progression ; Female ; Half-Life ; Humans ; Infant ; Infant, Newborn ; Liver Neoplasms/blood ; Liver Neoplasms/diagnosis* ; Liver Neoplasms/therapy ; Magnetic Resonance Imaging ; Male ; Neoplasm Recurrence, Local/drug therapy ; Neoplasm Recurrence, Local/mortality ; Neoplasms, Germ Cell and Embryonal/blood ; Neoplasms, Germ Cell and Embryonal/diagnosis* ; Neoplasms, Germ Cell and Embryonal/therapy ; Postoperative Complications ; Prognosis ; Retrospective Studies ; Tomography, X-Ray Computed ; alpha-Fetoproteins/metabolism*
Abstract
In a retrospective study, the prognostic value of monitoring the decay of alpha-fetoprotein (AFP) was assessed. Serum AFP was determined serially in 18 children with malignant germ-cell or hepatic tumors: 7 endodermal sinus tumor, 3 embryonal carcinoma, 5 malignant teratoma, 2 hepatoblastomas, and 1 hepatocellular carcinoma. The actual half-life (AHL) of AFP was computed after surgical resection of the tumor. In group 1, which had complete resection and no recurrence during follow-up (n = 13), the AHL of AFP was 4.0 ± 0.9 days. In group 2, which had incomplete resection or recurrence during follow-up (n = 5), the AHL of AFP was 24.8 ± 20 days, significantly longer than that of group 1 (P = 0.0026). The increased AHL of AFP indicated residual active tumor after surgical resection. The AHL of AFP may be more sensitive than serial monitoring of AFP in detecting preclinical recurrence after surgical resection of AFP-secreting tumors. Treatment strategies can be based on AFP clearance, and prospective clinical trials are warranted.
Full Text
https://link.springer.com/article/10.1007%2FBF01371908
DOI
10.1007/bf01371908
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Choi, Seung Hoon(최승훈)
Han, Seok Joo(한석주) ORCID logo https://orcid.org/0000-0001-5224-1437
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/177394
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