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Effects of Rebamipide in a Model of Experimental Diabetes and on the Synthesis of Transforming Growth Factor-b and Fibronectin, and Lipid Peroxidation Induced by High Glucose in Cultured Mesangial Cells
DC Field | Value | Language |
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dc.contributor.author | 김경환 | - |
dc.date.accessioned | 2020-07-03T17:12:14Z | - |
dc.date.available | 2020-07-03T17:12:14Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0022-3565 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177344 | - |
dc.description.abstract | Oxidative stress has been proposed as the basis for the pathogenesis of diabetic nephropathy. Rebamipide is a novel antiulcer drug that has, in addition, oxygen radical scavenging activity. Our study examines whether rebamipide could ameliorate the pathophysiology associated with experimental diabetes in vivo, such as microalbuminuria, and to reverse the increased production of transforming growth factor-beta1 and fibronectin in SV-40 transformed murine mesangial cells in culture that were stimulated with high glucose. Chronic administration of rebamipide (100 mg/kg/day, p.o., for 3 wk) to rats, in which diabetes was previously induced by the i.v. injection of streptozotocin 50 mg/kg, reversed hyperglycemia, which would contribute to prevent the increases in urinary excretion rates of albumin and lipid peroxides observed in this experimental model. Rebamipide, at this dose level, did not cause any discernible effect on age-matched control rats. Rebamipide 2 mM was as effective as 20 mM of dimethylthiourea, a known hydroxyl radical scavenger, in inhibiting the increase in lipid peroxides, transforming growth factor-beta1, fibronectin mRNAs and proteins induced by incubation of cultured mesangial cells with high glucose. Our data suggest that rebamipide attenuates high glucose-induced nephropathy, which is attributable, in part, to its antioxidative property and, in part, to its effect on reversing hyperglycemia. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics | - |
dc.relation.isPartOf | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Alanine/analogs & derivatives* | - |
dc.subject.MESH | Alanine/pharmacology | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Cells, Cultured | - |
dc.subject.MESH | Diabetes Mellitus, Experimental/drug therapy | - |
dc.subject.MESH | Enzyme Inhibitors/pharmacology* | - |
dc.subject.MESH | Fibronectins/biosynthesis | - |
dc.subject.MESH | Fibronectins/drug effects* | - |
dc.subject.MESH | Glucose/pharmacology* | - |
dc.subject.MESH | Lipid Metabolism* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Quinolones/pharmacology* | - |
dc.subject.MESH | Rats | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Transforming Growth Factor beta/biosynthesis | - |
dc.subject.MESH | Transforming Growth Factor beta/drug effects* | - |
dc.title | Effects of Rebamipide in a Model of Experimental Diabetes and on the Synthesis of Transforming Growth Factor-b and Fibronectin, and Lipid Peroxidation Induced by High Glucose in Cultured Mesangial Cells | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Pharmacology (약리학교실) | - |
dc.contributor.googleauthor | HUNJOO HA | - |
dc.contributor.googleauthor | SANG H. LEE | - |
dc.contributor.googleauthor | K. HWAN KIM | - |
dc.contributor.localId | A00311 | - |
dc.relation.journalcode | J03085 | - |
dc.identifier.eissn | 1521-0103 | - |
dc.identifier.pmid | 9190883 | - |
dc.identifier.url | http://jpet.aspetjournals.org/content/281/3/1457.long | - |
dc.contributor.alternativeName | Kim, Kyung Hwan | - |
dc.contributor.affiliatedAuthor | 김경환 | - |
dc.citation.volume | 281 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 1457 | - |
dc.citation.endPage | 1462 | - |
dc.identifier.bibliographicCitation | JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol.281(3) : 1457-1462, 1997 | - |
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