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Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors
DC Field | Value | Language |
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dc.contributor.author | 김세종 | - |
dc.contributor.author | 김종선 | - |
dc.contributor.author | 박전한 | - |
dc.contributor.author | 최인홍 | - |
dc.date.accessioned | 2020-07-03T17:10:32Z | - |
dc.date.available | 2020-07-03T17:10:32Z | - |
dc.date.issued | 1997 | - |
dc.identifier.issn | 0022-1767 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/177325 | - |
dc.description.abstract | NK cells express several inhibitory receptors that recognize class I MHC molecules expressed on target cells. The NK cell inhibitory receptors (KIRs) provide a key regulatory function for NK cells via specific interaction with MHC/peptide complexes, but the molecular details for recognition of class I MHC molecules by KIRs still remain unclear. Here we report cDNA cloning and expression of p58 KIRs and a p50 killer cell activatory receptor (KAR) from a Korean blood donor and demonstrate direct binding between recombinant soluble p58 KIRs and recombinant soluble HLA-C molecules. We identified three p58/p50 killer cell receptors (KAR-K1, KIR-K6, and KIR-K7), which are homologous to p50 cl-39, p58 47.11, and p58 cl-6, respectively. Native gel shift assay revealed that p58 KIR-K6 and KIR-K7 bind both HLA-Cw3 and HLA-Cw6 molecules, but p50 KAR-K1 binds neither of the HLA-C molecules. However, binding of HLA-C molecule by p58 KIR is affected by the antigenic peptide bound on the MHC molecule, suggesting that the p58 KIR binding to the HLA-C molecule may be dependent on the peptide. In addition, the binding interaction requires the presence of both p58 Ig domains, suggesting that the binding mode of HLA-C and p58 KIR may have some similarity to that of the neonatal Fc receptor and the Fc fragment of Ab and may be distinct from that of TCR and MHC. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Association of Immunologists | - |
dc.relation.isPartOf | JOURNAL OF IMMUNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.subject.MESH | Amino Acid Sequence | - |
dc.subject.MESH | Antigens/physiology | - |
dc.subject.MESH | Blood Donors | - |
dc.subject.MESH | Cloning, Molecular | - |
dc.subject.MESH | DNA, Complementary/isolation & purification | - |
dc.subject.MESH | HLA-C Antigens/chemistry | - |
dc.subject.MESH | HLA-C Antigens/genetics | - |
dc.subject.MESH | HLA-C Antigens/metabolism* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunoglobulins/physiology | - |
dc.subject.MESH | Killer Cells, Natural/metabolism* | - |
dc.subject.MESH | Molecular Sequence Data | - |
dc.subject.MESH | Peptides/immunology | - |
dc.subject.MESH | Peptides/physiology | - |
dc.subject.MESH | Protein Binding | - |
dc.subject.MESH | Protein Folding | - |
dc.subject.MESH | Protein Structure, Tertiary | - |
dc.subject.MESH | Receptors, Immunologic/biosynthesis | - |
dc.subject.MESH | Receptors, Immunologic/chemistry* | - |
dc.subject.MESH | Receptors, Immunologic/genetics | - |
dc.subject.MESH | Receptors, KIR | - |
dc.subject.MESH | Receptors, KIR2DL3 | - |
dc.subject.MESH | Receptors, Natural Killer Cell | - |
dc.subject.MESH | Solubility | - |
dc.title | Molecular basis of HLA-C recognition by p58 natural killer cell inhibitory receptors | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine (의과대학) | - |
dc.contributor.department | Dept. of Microbiology (미생물학교실) | - |
dc.contributor.googleauthor | Jongsun Kim | - |
dc.contributor.googleauthor | Yong Joon Chwae | - |
dc.contributor.googleauthor | Mi Yeon Kim | - |
dc.contributor.googleauthor | In Hong Choi | - |
dc.contributor.googleauthor | Jeon Han Park | - |
dc.contributor.googleauthor | Se Jong Kim | - |
dc.contributor.localId | A00603 | - |
dc.contributor.localId | A00921 | - |
dc.contributor.localId | A01641 | - |
dc.contributor.localId | A04167 | - |
dc.relation.journalcode | J01450 | - |
dc.identifier.eissn | 1550-6606 | - |
dc.identifier.pmid | 9378975 | - |
dc.identifier.url | https://www.jimmunol.org/content/159/8/3875.long | - |
dc.contributor.alternativeName | Kim, Se Jong | - |
dc.contributor.affiliatedAuthor | 김세종 | - |
dc.contributor.affiliatedAuthor | 김종선 | - |
dc.contributor.affiliatedAuthor | 박전한 | - |
dc.contributor.affiliatedAuthor | 최인홍 | - |
dc.citation.volume | 159 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 3857 | - |
dc.citation.endPage | 3882 | - |
dc.identifier.bibliographicCitation | JOURNAL OF IMMUNOLOGY, Vol.159(8) : 3857-3882, 1997 | - |
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